| ID | URL | Title | Summary | embedding_status | last_fetch |
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| 8451 |
https://www.lib.ncku.edu.tw/se... |
NCKU 成功大學-圖書館 |
(國立成功大學圖書館的網頁內容)，
2020年獲得圖書館OA補助文章之介紹
1. Epigenetic silencing of AATK in acinar to ductal metaplasia in murine model of pancreatic cancer：Ding et al. (2020) Clinical Epigenetics, 12(1), 87. Cite this article。Cancer subtype switching, which involves unclear cancer cell origin, cell fate decision, and transdifferentiation of cells within a confined tumor microenvironment, remains a major problem in pancreatic cancer (PDA). By analyzing PDA subtypes in The Cancer Genome Atlas, we identified that epigenetic silencing of Apoptosis Associated Tyrosine Kinase (AATK) inversely was correlated with mRNA expression and was enriched in the quasi-mesenchymal cancer subtype. By comparing early mouse pancreatic lesions, the non-invasive regions showed AATK co-expression in cells with acinar-to-ductal metaplasia, but the invasive lesions revealed diminished AATK expression in cells with poorly differentiated histology. Transiently activated AATK initiates acinar differentiation into a ductal cell fate to establish apical-basal polarization in acinar-to-ductal metaplasia. Silenced AATK and ectopically expressed p63 and HNF1α allow the proliferation of ductal PanINs in mice. Epigenetic silencing of AATK regulates the cellular transdifferentiation, proliferation, and cell cycle progression in converting PDA-subtypes。癌症亞型轉換涉及腫瘤微環境中的癌細胞起源，細胞命運決定以及細胞的轉分化，在胰臟癌至今仍是主要問題。藉由分析癌症基因組圖譜資料庫(TCGA)中的胰臟癌資料，我們發現凋亡相關酪氨酸磷酸酶基因AATK的表觀遺傳標定與mRNA表達成反比，此異常特徵富含於類間質腫瘤亞型。於小鼠早期胰臟組織病變發現，非侵入型病變細胞於此腺泡至導管轉分化時期仍有AATK蛋白表達，但在侵入型癌細胞病變則顯示出細胞分化不佳以及AATK蛋白表達減少的現象。AATK蛋白活化與腺泡至導管的型態轉換過程相關，並以此建立細胞的頂端-基底細胞極性。表觀遺傳默化的AATK基因和p63及HNF1α在小鼠胰臟上皮細胞病變增殖時期的異常表達相關。AATK基因的表觀遺傳默化在胰臟癌亞型轉化過程中的細胞轉分化，增殖和細胞週期進程具有調節能力與角色。
2. Evaluation of Vertical Ground Reaction Forces Pattern Visualization in Neurodegenerative Diseases Identification Using Deep Learning and Recurrence Plot Image Feature Extraction：Lin et al. (2020) Sensors, 20(14), 3857. Cite this article。To diagnose neurodegenerative diseases (NDDs), physicians have been clinically evaluating symptoms. However, these symptoms are not very dependable—particularly in the early stages of the diseases. This study has therefore proposed a novel classification algorithm that uses a deep learning approach to classify NDDs based on the recurrence plot of gait vertical ground reaction force (vGRF) data. In the preprocessing process, the 5-min vGRF data divided into 10-s successive time windows. In the feature transformation process, the time-domain vGRF data are modified into an image using a recurrence plot. The principal component analysis (PCA) is used in this stage for feature enhancement. Lastly, the convolutional neural network (CNN), as a deep learning classifier, is employed in the classification process and evaluated using the leave-one-out cross-validation (LOOCV). The experimental results included two-class and multiclass classifications with the best average accuracy were 98.65% and 97.86%, respectively。為了診斷神經退化性疾病(NDDs)，醫師們已在臨床上評估其症狀。然而這些症狀卻不是相當可靠，尤其是在疾病早期的階段。這項研究便提出一種深度學習方式使用基於步態垂直地面反應力(vGRF)遞迴圖的創新分類演算法達到對神經退化性疾病分類。在前處理中，將5分鐘的垂直地面反應力資料切割成每10秒的連續時間視窗。在特徵轉換過程中，時域的垂直地面反應力資料被轉成遞迴圖影像。主成分分析(PCA)被用以特徵強化。最後分類的過程中，以深度學習卷積類神經網路(CNN)作為分類器，並使用留一交叉驗證法(LOOCV)進行評估。實驗的分類結果包含兩類與多類，其最佳平均準確率分別為98.65%與97.86%。
3. Differentiating anomalous disease intensity with confounding variables in space：Wu, C.-C., & Shete, S. (2020). International Journal of Health Geographics, 19(1), 37. Cite this article。With the identification of disease clusters of statistical significance, to determine whether or not the detected disease clusters can be explained by known or suspected risk factors is a logical next step. The models allowing for confounding variables permit the investigators to determine if some risk factors can explain the occurrence of geographical clustering of disease incidence and to investigate other hidden spatially related risk factors if there still exist geographical disease clusters, after adjusting for risk factors.We propose to develop statistical methods for differentiating incidence intensity of geographical disease clusters of peak incidence and low incidence in a hierarchical manner, adjusted for confounding variables.With the information on hierarchy in adjusted intensity levels, epidemiologists and public health officials can better prioritize the regions with the highest rates for thorough etiologic studies, seeking hidden spatially related risk factors and precisely moving resources to areas with genuine highest abnormalities。加入共變量調整危險因子後，來辨別地域群聚內不同疾病強度的統計方法，可以在地圖上分別建構彼此相鄰並具有不同強度的高風險區與低風險區的階級式(強度方面)群聚。隨著模型加入共變量進行調整，研究人員能夠決定一些風險因子是否可以解釋彼此相鄰的高風險區或低風險區中地域群聚的發生。
4. Long Short-Term Memory Approach to Estimate Battery Remaining Useful Life Using Partial Data：Chinomona, B., Chung, C., Chang, L.-K., Su, W.-C., & Tsai, M.-C. (2020). IEEE Access, 8, 165419–165431. Cite this article。Due to the increasing demand of electrical vehicles, prognostics of the battery state is of paramount importance. The nonlinearity of the signal results in the complexity of analyzing the degradation of the battery. The drawbacks of the previous prediction algorithms are insufficient or irrelevant features to explicitly model the battery aging and use of fully charged/discharged datasets, which might result in poor prediction accuracy. Therefore, this study proposes a feature selection technique to adequately select optimum statistical feature subset and the use of partial data to determine the battery remaining useful life (RUL). The proposed approach demonstrated exceptional RUL prediction results, with RMSE of 0.00286 and MAE of 0.00222 using partial discharge data. The method shows prediction in comparison with the use of full data and state-of-the-art outcomes from previous studies of the same open data from the National Aeronautics and Space Administration prognostic battery data sets。由於電動車的需求增加，對於電池狀態的預知也變得非常重要，而電池相關訊號的非線性讓電池衰退的分析變得複雜。因此，本研究提出了新的特徵選擇技術來選用合適的特徵組合，並以部分資料的方式來進行電池剩餘壽命預估，利用使用部分資料的技術可以得到0.00288的均方根誤差以及0.00222的平均絕對誤差。對照其他學者使用同樣美國太空總署公開電池充放電資料所得的研究成果，此研究提出的方法展現了更好的準確度。
5. Anti-IL-20 antibody improved motor function and reduced glial scar formation after traumatic spinal cord injury in rats：Lee, J.-S., Hsu, Y.-H., Chiu, Y.-S., Jou, I.-M., & Chang, M.-S. (2020). Journal of Neuroinflammation, 17(1), 156. Cite this article。Spinal cord injury (SCI) causes neurological devastating consequences, which result in partial or total paralysis. The irreversible neurological deficits and glial scar formation are characteristic of SCI. Inflammatory responses play a central role in regulating the pathogenesis of SCI. IL-20 is a proinflammatory cytokine involved in renal fibrosis and liver cirrhosis through upregulating TGF-β1 production. However, the role of IL-20 in SCI remains unclear. We used the in-vivo and in-vitro studies to delineate the association between IL-20 and SCI. We found that IL-20 was highly expressed in spinal cord after SCI in rats and upregulated the expression levels of inflammatory cytokines, whereas anti-IL-20 mAb 7E treatment remarkably inhibited the inflammatory response through inhibiting the levels of IL-20 and TGF-β1. Both motor and sensory functions were improved with anti-IL-20 mAb 7E treatment. These findings give evidence that IL-20 may be a promising target for SCI treatment。脊髓損傷會因為神經功能障礙造成永久癱瘓，神經損傷的不可逆性和神經疤痕的形成是脊髓損傷的主要特徵，其中發炎反應是脊髓損傷最重要的致病機轉，介白質-20(IL-20)是一種前驅發炎反應的細胞激素，參與很多臨床疾病相關發炎反應，例如肝硬化、慢性腎衰竭等，目前並無相關的研究在於脊髓損傷方面。我們利用動物和細胞實驗來研究介白質-20對外傷性脊髓損傷影響。我們發現損傷後會大量表現介白質-20，在抑制介白質-20後相關的發炎反應都大量降低，同時在運動和感覺功能上有顯著的進步，這些發現提供了未來利用抑制介白質-20在治療脊椎損傷的治療方向。
6. Progress in biomass torrefaction: Principles, applications and challenges：Chen, W.-H., Lin, B.-J., Lin, Y.-Y., Chu, Y.-S., Ubando, A. T., Show, P. L., Ong, H. C., Chang, J.-S., Ho, S.-H., Culaba, A. B., Pétrissans, A., & Pétrissans, M. (2021). Progress in Energy and Combustion Science, 82, 100887. Cite this article。The development of biofuels has been considered as an important countermeasure to abate anthropogenic CO2 emissions and greenhouse effect. Thermochemical conversion processes are considered as the most efficient routes. In recently developing biomass conversion technologies, torrefaction has attracted much attention since it can effectively upgrade solid biomass and produce coal-like fuel. To provide a comprehensive review of the progress in biomass torrefaction technologies, this study performs an in-depth literature survey of torrefaction principles, processes, systems, and identifies a current trend in practical torrefaction development, and environmental performance. Moreover, the encountered challenges and perspectives from torrefaction development are underlined. Integrating torrefaction with other processes such as co-firing, gasification, pyrolysis, and ironmaking, etc., makes it more efficient and economically feasible in contrast to using a single process. By virtue of capturing carbon dioxide during the growth stage of biomass, negative carbon emissions can even be achieved from torrefied biomass。生質燃料的開發是減緩溫室效應的重要途徑，焙燒被認為是最有效的熱化學轉化技術，由於焙燒產出之固體燃料可用於替代煤炭，本研究對焙燒原理、程序及系統進行廣泛的文獻整理，並歸納焙燒技術當前在實際應用和環境效益的趨勢，亦強調焙燒技術開發的瓶頸。研究顯示將焙燒與混燒、氣化、熱裂解等製程進行整合能提升系統效率。
7. Roles of Macrophage Migration Inhibitory Factor in Dengue Pathogenesis: From Pathogenic Factor to Therapeutic Target：Lai, Y.-C., Chao, C.-H., & Yeh, T.-M. (2020). Microorganisms, 8(6). Cite this article。Dengue virus (DENV) infection is the most prevalent mosquito-borne viral infection and can lead to severe dengue hemorrhagic fever (DHF) and even life-threatening dengue shock syndrome (DSS). Although the cytokine storm has been revealed as a critical factor in dengue disease, the limited understanding of dengue immunopathogenesis hinders the development of effective treatments. Macrophage migration inhibitory factor (MIF) is a pleiotropic proinflammatory cytokine that mediates diverse immune responses, and the serum level of MIF positively correlates with disease severity in patients with dengue. MIF is involved in DENV replication and many pathological changes, such as vascular leakage, during DENV infection. In this paper, the pathogenic roles of MIF and the regulation of MIF secretion during DENV infection are reviewed. Furthermore, whether MIF is a potential therapeutic target against DENV infection is also discussed。登革病毒感染是最普遍的蚊媒病毒感染，可導致嚴重的登革出血熱甚至威脅生命的登革休克綜合徵。儘管已經知道細胞激素風暴是登革熱的關鍵因素，但是對登革熱免疫發病機制的了解仍有限，因此阻礙了有效治療方法的發展。巨噬細胞移動抑制因子（MIF）是一種多效性促炎細胞激素，可介導多種免疫反應，並且MIF的血清濃度與登革熱患者的疾病嚴重程度呈正相關。 目前已知MIF參與登革病毒感染期間的許多病理變化，例如血管滲漏。本文綜述了登革病毒感染過程中MIF的致病機轉和MIF分泌的調控。此外，也討論了MIF是否是抗登革病毒感染的潛在治療靶標。
8. Global greenness in relation to reducing the burden of cardiovascular diseases: ischemic heart disease and stroke：Asri, A. K., Yu, C.-P., Pan, W.-C., Guo, Y. L., Su, H.-J., Lung, S.-C. C., Wu, C.-D., & Spengler, J. D. (2020). Environmental Research Letters, 15(12), 124003. Cite this article。This ecological study aimed to identify the association between greenness and cardiovascular diseases in terms of ischemic heart disease (IHD) and stroke in 183 countries worldwide. The country-level disability-adjusted life year (DALY) database provided by the WHO was used to represent the health burden due to IHD and stroke for the study countries. Normalized Difference Vegetation Index (NDVI) was assessed to estimate the greenness in each country. After considering potential covariates, the generalized linear mixed model penalized quasi-likelihood (GLMMPQL) was applied to identify the greenness in relation to DALY loss due to IHD and stroke. A consistently significant negative association was found between greenness and both IHD and stroke; the NDVI coefficients of the main model were -11.245 (95% CI: -16.770, -5.720) and -4.387 (95% CI: -7.926, -0.085), respectively, in the DALY changes based on the increase of NDVI from 0 to 1。 本研究利用世界衛生組織提供之全球失能調整生命年資料庫，代表由於缺血性心臟病與中風所造成之疾病負擔；以及衛星常態化差異植生指標，以量化各國之綠覆情況，經由廣義線性混合模式，分析環境綠蔽度與心血管疾病之關聯。結果發現，在校正風險因子的情況下，綠蔽度與缺血性心臟病及中風具顯著負相關。
9. Carcinogenesis of Male Oral Submucous Fibrosis Alters Salivary Microbiomes：Chen, M. Y., Chen, J. W., Wu, L. W., Huang, K. C., Chen, J. Y., Wu, W. S., Chiang, W. F., Shih, C. J., Tsai, K. N., Hsieh, W. T., Ho, Y. H., Wong, T. Y., Wu, J. H., & Chen, Y. L. (2020). Journal of Dental Research. Cite this article。Most oral squamous cell carcinoma (OSCC) tumors arise from oral premalignant lesions. Oral submucous fibrosis (OSF) is a premalignant stromal disease characterized by a high malignant transformation rate and high prevalence. Although a relationship between the inhabited microbiome and carcinogenesis has been proposed, the changes of the salivary microbiome during cancer formation remain unclear. This study compared the salivary microbiomes of male patients with OSCC and a predisposing OSF background (OSCC-OSF group). The results of high-throughput sequencing of the bacterial 16S rRNA gene indicated that the microbiome profile of OSF-related malignancy was associated with increased microbial stochastic fluctuation. Artificial intelligence selection algorithms consistently identified 5 key species in the OSCC-OSF group. Robust accuracy in predicting oral carcinogenesis was obtained with our exploratory and validation data sets. In conclusion, our results provided new insights into salivary microbiome alterations during the malignant transformation of OSF。 口腔粘膜下纖維化（OSF）一種口腔癌前病變，常惡轉為口腔癌（OSCC）。微生物常被視為人類第二套基因組和人類健康及疾病關係密切，本研究利用分析唾液微生物組的變化，期望找到影響OSF惡轉為OSCC的關鍵微生物群。我們發現在OSCC唾液微生物組的共生網絡崩潰，且以人工智慧演算法找出OSCC組中的5個關鍵微生物物種可以預測口腔癌的發生。
10. Anti-Cancer Effect of Cordycepin on FGF9-Induced Testicular Tumorigenesis：Chang, M.-M., Hong, S.-Y., Yang, S.-H., Wu, C.-C., Wang, C.-Y., & Huang, B.-M. (2020). International Journal of Molecular Sciences, 21(21). Cite this article。Cordycepin, a bioactive constituent from the fungus Cordyceps sinensis, could inhibit cancer cell proliferation and promote cell death via induction of cell cycle arrest, apoptosis and autophagy. We observed that cordycepin down-regulated the mRNA levels of FGF9, FGF18, FGFR2 and FGFR3 genes in MA-10 cells. The in vitro study revealed that cordycepin decreased FGF9-induced MA-10 cell proliferation by inhibiting p-ERK1/2, p-Rb and E2F1 expressions, and reducing the expressions of cyclins and CDKs. Moreover, an allograft model was performed with FGF9 intratumoral injection and/or intraperitoneal cordycepin injection to MA-10-tumor bearing C57BL/6J mice. Results showed that FGF9-induced tumor growth in cordycepin-treated mice was significantly smaller than PBS-treated control group. Furthermore, cordycepin decreased FGF9-induced FGFR1-4 protein expressions in vitro and in vivo. In summary, cordycepin inhibited FGF9-induced testicular tumor growth by suppressing the ERK1/2, Rb/E2F1, cell cycle pathways, and FGFR1-4 expressions, suggesting cordycepin can be used as novel anticancer drug for testicular cancers。 蟲草素是具有抗腫瘤作用的冬蟲夏草萃取物。微陣列分析顯示，蟲草素會降低MA-10細胞中纖維母細胞生長因子九(FGF9)與其受體基因表達。蟲草素也可顯著降低FGF9對MA-10細胞增生作用。蟲草素亦可抑FGF9處理的MA-10細胞中pRb、E2F1、cyclins、CDKs與FGFR1-4蛋白表達。蟲草素也能夠抑制FGF9處理的小鼠皮下腫瘤生長。因此，蟲草素具有治療睾丸癌症的新型抗癌藥物。
11. Investigation of Ga2O3-Based Deep Ultraviolet Photodetectors Using Plasma-Enhanced Atomic Layer Deposition System：Chu, S.-Y., Shen, M.-X., Yeh, T.-H., Chen, C.-H., Lee, C.-T., & Lee, H.-Y. (2020). Sensors, 20(21). Cite this article。In this work, the gallium oxide (Ga2O3) films were deposited using a plasma-enhanced atomic layer deposition system. The performance of the Ga2O3 films annealed at various temperatures was investigated using X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and photoluminescence (PL). According to the measurement results, the performance of the Ga2O3 films was improved with the annealed temperature increase. The Ga2O3 films were applied to the deep metal-semiconductor-metal ultraviolet C photodetectors (MSM UVC-PDs). The cut-off wavelength and the photoresponsivity of the MSM UVC-PDs were 250 nm and 22.19 A/W, respectively。此研究中使用電漿增強式原子層沉積系統沉積氧化鎵薄膜，並研究在不同溫度下熱退火處理對氧化鎵薄膜特性之影響，利用X光繞射光譜、X光光電子能譜與光致發光光譜的量測結果顯示氧化鎵薄膜品質隨著退火溫度升高而有改善趨勢。將此氧化鎵薄膜應用於金屬-半導體-金屬深紫外光光檢測器，其元件截止波長為250 nm及響應度為22.19 A/W。
12. Dynamic Modeling and Experimental Validation of an Impact-Driven Piezoelectric Energy Harvester in Magnetic Field：Chen, C.-D., Wu, Y.-H., & Su, P.-W. (2020). Sensors, 20(21), 6170. Cite this article。In this study, an impact-driven piezoelectric energy harvester (PEH) in magnetic field is presented. The PEH consists of a piezoelectric cantilever beam and plural magnets. The impact between magnets produces an impact energy and causes a transient beam vibration. The electric energy is generated by the piezoelectric effect. Based on the energy principle, a multi-degree of freedom mathematical model was developed to calculate the displacements, velocities, and voltage outputs of the PEH. A prototype of the PEH was fabricated. The maximum generated energy was about 0.4045 mJ for a single impact. A comparison between numerical and experimental results was presented in detail. It showed that the predictions based on the model agree with the experimental measurements. The PEH was connected to a diode bridge rectifier and a storage capacitor. The experiments showed that the energy stored in the capacitor can light up the LED。 本研究提出一種由磁力產生撞擊驅動之壓電獵能器，並發展多自由度之數學模型，可計算獵能器做動時之位移、速度以及電壓輸出。本研究亦完成獵能器原型實作，單次撞擊可獵取0.4045 mJ之能量，顯示數學模型可正確預測獵能器之發電性能。壓電獵能器亦接上橋式整流器，將獵取之電荷儲存於電容中，並將電容儲存之電能釋放，點亮LED燈。
13. Single Crystalline Higher Manganese Silicide Nanowire Arrays with Outstanding Physical Properties through Double Tube Chemical Vapor Deposition：Shen, C.-L., Yang, S.-M., & Lu, K.-C. (2020). Nanomaterials, 10(9), 1880. Cite this article。In this work, we report a novel and efficient silicidation method to synthesize higher manganese silicide (HMS) nanowires with interesting characterization and physical properties. High density silicon nanowire arrays fabricated by chemical etching reacted with MnCl2 precursor through a unique double tube chemical vapor deposition (CVD) system, where we could enhance the vapor pressure of the precursor and provide stable Mn vapor with a sealing effect. It is crucial that the method enables the efficient formation of high quality higher manganese silicide nanowires without a change in morphology and aspect ratio during the process. X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) were utilized to characterize the HMS nanowires. High-resolution TEM studies confirm that the HMS nanowires were single crystalline Mn27Si47 nanowires of Nowotny Chimney Ladder crystal structures. The excellent physical properties of the HMS nanowires (NWs) make them attractive choices for applications in spintronic devices and field emitters。 此研究中，我們使用一種新穎而有效的矽化方法，合成富矽化錳奈米線。通過化學蝕刻製造高密度的矽奈米線陣列且通過獨特的雙管化學氣相沉積系統與前驅物反應。在該系統中，我們增強前驅物的蒸氣壓並提供具有密封效果的穩定錳蒸氣。此方法有效形成高質量的富矽化錳奈米線，而且在過程中不會改變形貌和高寬比。富矽化錳奈米線的優異物理特性使其可望應用於自旋電子元件與場發射器。
14. Chitosan Oligosaccharides Suppress Nuclear Factor-Kappa B Activation and Ameliorate Experimental Autoimmune Uveoretinitis in Mice：Hsu, S.-M., Yang, C.-H., Tsai, H.-Y., Lin, C.-J., Fang, Y.-H., Shieh, C.-C., & Chen, S.-H. (2020). International Journal of Molecular Sciences, 21(21). Cite this article。We investigated the therapeutic potential and mechanism of chitosan oligosaccharides (COS) for experimental autoimmune uveoretinitis (EAU) in mice. EAU was induced in C57/BL6 mice by injection of human interphotoreceptor retinoid binding protein (IRBP) peptides. At the same time, a high or low dose (20 or 10 mg/kg) of COS or phosphate buffered saline (PBS) was given to mice daily after EAU induction. We found that mouse EAU is ameliorated by the high-dose COS treatment when compared with PBS treatment. In the retinas of high-dose COS-treated mice, the nuclear translocation of NF-κB subunit (p65) was suppressed, and the expression of several key EAU inflammatory mediators, IFN-γ, TNF-α, IL-1α, IL-4, IL-5, IL-6, IL-10, IL-17, and MCP-1 was lowered. These results suggest that COS might be a potential treatment for posterior uveitis。 背景:葡萄膜炎是造成眼睛視力喪失主要原因之一，非感染造成之自體免疫性後葡萄膜視網膜炎對視力影響比前葡萄膜炎更大，目前主要使用類固醇來控制與治療，但有明顯副作用如白內障與青光眼等，殼聚醣(chitosan)來自於甲殼素部分分解而成，已知有許多生物活性如抗癌、抗菌、抗發炎、抗氧化與抗凋亡等，在本研究中我們想探討殼聚醣在小鼠對實驗性自體免疫性葡萄膜視網膜炎之治療潛力與機制。 方法:藉由在B6小鼠注射人類感光體間類視黃醇結合蛋白(IRBP)胜肽可誘發實驗性自體免疫性葡萄膜視網膜炎。在誘發的同時開始，我們每天注射高與低劑量的殼聚醣做治療或是每天注射磷酸緩衝溶液作為對照。我們也取下小鼠的神經視網膜做發炎介質之分析與研究核因子κB(NF-κB)是否活化。 結果:首先我們發現與對照組(注射磷酸緩衝溶液)的小鼠相比，每天注射高劑量殼聚醣的小鼠其誘發的實驗性自體免疫性葡萄膜視網膜炎明顯減弱，在臨床眼底觀察與摘下眼睛做H&E切片染色皆可看到相似結果，同時我們發現高劑量殼聚醣治療的小鼠其視網膜上核因子κB往核內易位明顯受到抑制，且許多種關鍵性的發炎介質包括IFN-γ，TNF-α，IL-1α，IL-4，IL-5，IL-6，IL-10，IL-17與MCP-1都有顯著下降。 結論: 在本研究中我們證實殼聚醣的治療確實可以經由抑制核因子κB的活化減緩實驗性自體免疫性葡萄膜視網膜炎之嚴重程度，未來殼聚醣有可能用來治療人類非感染性後葡萄膜炎。
15. Direct synthesis of monolayer gold nanoparticles on epoxy based photoresist by photoreduction and application to surface-enhanced Raman sensing：Chen, Y.-J., Chang, W.-H., Li, C.-Y., Chiu, Y.-C., Huang, C.-C., & Lin, C.-H. (2021). Materials & Design, 197, 109211. Cite this article。The photoreduction method is a potential method in terms of simplification, speed, and cost of the process. This paper presents a simple, novel, and inexpensive method for the direct synthesis of a gold nanoparticle (AuNP) monolayer with a droplet of gold precursor on the surface of SU-8 under UV exposure, and its application to surface enhanced Raman sensing (SERS). TEM study revealed that a monolayer of AuNPs with an fcc crystalline structure was reduced on the surface of SU-8. The interparticle spacing and particle size were adjustable by controlling SU-8 initial curing time and repeated reduction. Photoreduction on SU-8 nanostructures was also achievable. The nanopillars' high specific surface area can help improve the density of the SERS hot spots, thereby effectively improving the analyte's Raman signal. The AuNPs/nanopillar substrate was applied to the detection of malachite green (aquaculture drug), and the sensitivity is enough to meet the EU regulations。 應用光還原法生成金奈米粒子，在製程的簡化、速度與成本上都極具潛力。本研究提出一個簡單、新穎且便宜的方法，將滴在SU-8表面上的氯金酸液滴進行UV曝光，製作出單層金奈米粒子並應用於表面增強拉曼感測。SU-8的初始固化時間與重複還原的次數可以調控金奈米粒子的密度與粒徑，透過這兩個參數的調控與SU-8奈米柱結構高比表面積的特性能提升表面增強拉曼散射熱點的強度與密度，進而有效提高待測物的拉曼訊號。此金奈米粒子/奈米柱基板可用來檢測水產用藥(孔雀石綠)，靈敏度能滿足歐盟判定漁貨殘留藥物含量之標準。
16. Single-Cell Analysis of Different Stages of Oral Cancer Carcinogenesis in a Mouse Model：Huang, L.-Y., Hsieh, Y.-P., Wang, Y.-Y., Hwang, D.-Y., Jiang, S. S., Huang, W.-T., Chiang, W.-F., Liu, K.-J., & Huang, T.-T. (2020). International Journal of Molecular Sciences, 21(21). Cite this article。在小鼠模型中不同階段口腔癌致癌的單細胞分析口腔癌爲涉及正常粘膜發展為潛在的惡性疾病，最後發展為癌症之病症。腫瘤是異質的，具有表達不同基因並表現出不同行為的不同細胞族群。 本研究用4-硝基喹啉1-氧化物（4-NQO）和檳榔鹼誘導小鼠發生口腔癌，並通過單細胞RNA測序分析確定影響癌變基因表達的主要因素。
17. A New High Entropy Glycerate for High Performance Oxygen Evolution Reaction：Nguyen, T. X., Su, Y.-H., Lin, C.-C., Ruan, J., & Ting, J.-M. (2021). Advanced Science, 2002446. Cite this article。Herein, a new high entropy material is reported, i.e., a noble metal‑free high entropy glycerate (HEG), synthesized via a simple solvothermal process. The HEG consists of 5 different metals of Fe, Ni, Co, Cr, and Mn. The unique glycerate structure exhibits an excellent oxygen evolution reaction (OER) activity with a low overpotential of 229 and 278 mV at current densities of 10 and 100 mA cm−2, respectively, in 1 m KOH electrolyte, outperforming its subsystems of binary‑, ternary‑, and quaternary‑metal glycerates. The HEG also shows outstanding stability and durability in the alkaline electrolyte. The result demonstrates the significance of synergistic effect that gives additional freedoms to modify the electronic structure and coordination environment. Moreover, HEG@HEG electrolyzer shows a good overall water splitting performance and durability, requiring a cell voltage of 1.63 V to achieve a current density of 10 mA cm−2。 新穎高熵甘油酸酯氧釋放反應催化劑本研究透過簡易的溶劑熱合成法合成無貴金屬之高熵甘油酸酯(HEG)。此HEG由鐵、鎳、鈷、鉻和錳5種不同的金屬組成，其獨特的甘油酸酯結構展現出優異的氧釋放反應活性，在1M KOH電解液中分別可在10和100 mA cm-2電流密度下獲得229和278 mV優異的低過電位，更勝於其二、三與四元金屬系統，同時更有著出色的穩定性和耐久性，顯現了協同效應在高熵材料中的重要性。 |
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(以下為國立成功大學圖書館網頁內容)，
2024年獲得圖書館OA補助文章之介紹 服務辦法
1. The Challenges in Using eHealth Decision Resources for Surrogate Decision-Making in the Intensive Care Unit. Sun, W.-N., & Kao, C.-Y. (2024). J Med Internet Res, 26, e47017. Read this article; The mortality rate in intensive care units (ICUs) is notably high, with patients often relying on surrogates for critical medical decisions due to their compromised state. This study then introduces eHealth literacy and the assessment tools to evaluate users’ capability and literacy levels in using eHealth resources. A clinical scenario involving surrogate decision-making is presented. This simulated case involves a patient with a hemorrhagic stroke who has lost consciousness and requires medical procedures such as tracheostomy. However, due to the medical surrogate’s lack of familiarity with eHealth devices and limited literacy in using eHealth resources, difficulties arise in assisting the patient in making medical decisions. This scenario highlights challenges related to eHealth literacy and solution strategies are proposed. In conclusion, effective ICU decision-making with eHealth tools requires a careful balance between efficiency with inclusivity. Health professionals should adopt a patient-centered approach to enhance the decision-making experience, particularly for individuals with limited eHealth literacy.; 加護病房死亡率相當高，病人通常因病情危急而需要代理人做出重要的醫療決策。本文介紹智慧醫療素養及其評估工具，來評估使用者對於智慧醫療資源使用及健康素養水平。本文模擬臨床情境，假設一位病人因出血性中風喪失意識，但須要面臨氣管切開術等醫療處置，然而，代理人對於使用智慧醫療相關設備不熟悉，且健康素養水平有限的情況下，使代理人出現決策困難，這樣的情境凸顯現今推行智慧醫療設備使用及健康素養水平不同的困境。特別在加護病房時，醫療團隊使用智慧醫療設備進行決策輔助時，需在決策效率及代理人的差異上取得平衡，醫療團隊應以病人為中心，提升代理人決策歷程感受，特別在健康素養較低的代理人。
2. Impact of Antenatal SARS-CoV-2 Exposure on SARS-CoV-2 Neutralization Potency. Chiang, C.-J., Hsu, W.-L., Su, M.-T., Ko, W.-C., Hsu, K.-F., & Tsai, P.-Y. (2024). Vaccines, 12(2), 164. Read this article; A pregnancy booster dose significantly reduces the risk and severity of COVID-19, and it is widely recommended. A prospective cohort study was conducted to compare the transplacental passage of maternal antibodies from vaccination or infection during three trimesters against both the vaccine-targeted Wuhan strain and the Omicron strain of SARS-CoV-2. Maternal-infant dyads from vaccinated mothers were collected between 6 June 2022 and 20 September 2022. We analyzed 38 maternal-infant dyads from mothers who had been infected with COVID-19 and 37 from mothers without any previous infection. Pregnant women who received their last COVID-19 vaccine dose in the third trimester exhibited the highest anti-spike protein antibody levels and neutralizing potency against both the Wuhan strain and Omicron BA.2 variant in their maternal and cord plasma. Both second- and third-trimester vaccination could lead to a higher level of neutralization against the Wuhan and Omicron strains. COVID-19 infection had a negative effect on the transplacental transfer ratio of SARS-CoV-2 antibodies. A booster dose during the second or third trimester is encouraged for the maximum transplacental transfer of humoral protection against COVID-19 for infants.; 妊娠追加疫苗可顯著降低感染 COVID-19 的風險和嚴重程度，因此受到廣泛推薦。進行了一項前瞻性研究，比較了針對疫苗的武漢株和 SARS-CoV-2 的 Omicron 株，在三個月內接種疫苗或感染而產生的母源抗體的經胎盤傳遞情況。 在2022 年6 月6 日至2022 年9 月20 日期間收集已接種疫苗的母嬰檢體。在妊娠晚期接受最後一劑 COVID-19 疫苗的孕婦在母體和臍帶血漿中表現出最高的抗尖峰蛋白抗體水平和針對武漢毒株和 Omicron BA.2 變種的中和效力。妊娠中期和晚期的疫苗接種都可能導致針對武漢病毒株和 Omicron 病毒株的更高水平的中和作用。 COVID-19 感染對 SARS-CoV-2 抗體的經胎盤轉移率有負面影響。鼓勵在妊娠中期或晚期注射加強劑，以最大程度地透過胎盤轉移針對嬰兒的 COVID-19保護。
3. Empirical dynamic modeling for sustainable benchmarks of short-lived species. Tsai, C.-H., Munch, S. B., Masi, M. D., & Stevens, M. H. (2024). ICES Journal of Marine Science. Read this article; The paper introduces Empirical Dynamic Modeling (EDM) as a cutting-edge approach to improve sustainable management for short-lived species like Penaeidae brown shrimp, which exhibit highly fluctuating and chaotic dynamics. Traditional methods often overlook critical factors such as unobserved species interactions, leading to less accurate predictions. EDM stands out by effectively capturing these hidden interactions, providing more reliable forecasts of population responses to fishing pressures. Applied to U.S. Gulf of Mexico brown shrimp, EDM proved highly effective, leading to more sustainable and adaptive fisheries management that truly reflects the complexity of marine ecosystems.; 這篇論文介紹了一種經驗動態建模（EDM），用以改善對於如Penaeidae棕蝦等生命週期短、族群動態波動劇烈物種的永續管理方法。傳統漁業管理模型往往忽略了關鍵因素，例如生態系統中許多無法觀察到的物種間交互作用，導致模型預測的準確性降低。而EDM能有效捕捉這些隱藏的交互作用，提供在不同捕撈影響下的族群動態反應可靠預測。在應用EDM於美國墨西哥灣的棕蝦族群時，EDM可以有效地增進可持續性和適應性的漁業管理，更真實地反映了海洋生態系統的複雜性。
4. Nurses’ Knowledge and Skills After Use of an Augmented Reality App for Advanced Cardiac Life Support Training: Randomized Controlled Trial. Sun, W.-N., Hsieh, M.-C., & Wang, W.-F. (2024). J Med Internet Res, 26, e57327. Read this article; In a medical center in southern Taiwan, the study involved 102 nurses divided into an AR group and a control group receiving traditional lecture-based instruction. The AR group used an interactive crash cart learning system developed with AR technology. Both groups were assessed on knowledge and practical skills, with subgroup analyses focusing on nurses with less than two years of experience. Results demonstrated that the AR group significantly outperformed the control group in overall ACLS outcomes and crash cart usage (P = .002; P = .01). Nurses with less experience showed the most substantial improvements in knowledge and skills (P < .001). Additionally, the AR group reported higher motivation (IMMS mean: 141.65), better usability (SUS mean: 90.47), and reduced cognitive load (mean: 15.42) compared to traditional methods. These findings highlight AR as an effective tool for enhancing ACLS training, especially for less experienced nurses.; 這個研究在南台灣的醫學中心進行，共納入102名護理師。實驗組使用AR技術開發的互動式急救車學習系統，而對照組使用傳統授課方式。兩組參與者均接受了知識與技能的評估，並對工作小於兩年的護理師進行次分析。研究結果發現，實驗組在ACLS進階心臟救命術整體學習成效，和急救車的學習成效顯著優於對照組（P = .002；P = .01）。其中，工作小於兩年的護理師在知識和技能方面的提升最為顯著（P < .001）。此外，相較於傳統方法，實驗組在學習動機（IMMS平均值：141.65）、系統可用性（SUS平均值：90.47）以及降低認知負荷（平均值：15.42）方面也表現更佳。這些結果突顯了AR技術在增強ACLS訓練方面的有效性，尤其對於經驗較少的護理師具有顯著幫助。
5. Molecular characterization of colistin-resistant Klebsiella pneumoniae isolates and their conjugative mcr-carrying plasmids. Kao, C.-Y., Kuo, P.-Y., Lin, C.-C., Cheng, Y.-Y., Wang, M.-C., Chen, Y.-C., & Lin, W.-H. (2024). Journal of Infection and Public Health, 17(12), 102588. Read this article; This study investigates colistin-resistant Klebsiella pneumoniae (CoRKp) isolated from patients with urinary tract infections and bacteremia at a Taiwanese teaching hospital from 1999 to 2022. Among 1966 K. pneumoniae isolates, 21 were CoRKp, including 12 multidrug-resistant (MDR) and 4 extensively drug-resistant (XDR) strains. Whole genome sequencing revealed diverse sequence types (STs) and capsular types. Two isolates, SC-KP169 and SC-KP585, carried transferable mcr-1 and mcr-8 plasmids, respectively. The mcr-1-carrying plasmid enhanced virulence in K. pneumoniae, while mcr-8 did not affect virulence in Escherichia coli. Mutations in phoQ, pmrA, pmrB, and mgrB genes and insertion elements contributed to resistance mechanisms. The study highlights the potential public health risk posed by the spread of mcr-mediated resistance and emphasizes the need for surveillance and control strategies.; 本研究調查1999年至2022年間台灣某醫學中心從泌尿道感染及菌血症患者中分離的抗黏菌素耐藥型克雷伯氏肺炎桿菌(CoRKp)。在1966株分離株中，有21株為CoRKp，其中12株為多重抗藥性(MDR)，4株為廣泛抗藥性(XDR)。全基因組測序揭示其具多樣的序列型(ST)和莢膜型。兩株菌株SC-KP169和SC-KP585攜帶可轉移的mcr-1與mcr-8質粒。mcr-1質粒增加了克雷伯氏肺炎桿菌的毒力，而mcr-8對大腸桿菌的毒力無顯著影響。基因phoQ、pmrA、pmrB及mgrB的突變和插入序列是引起抗藥性機制的關鍵。本研究凸顯mcr介導的抗藥性傳播對公共衛生的潛在威脅，並強調持續監測與控制策略的重要性。 |
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1. Investigation of High‑Sensitivity NO2 Gas Sensors with Ga2O3 Nanorod Sensing Membrane Grown by Hydrothermal Synthesis Method.
Chu, S.-Y., Wu, M.-J., Yeh, T.-H., Lee, C.-T., & Lee, H.-Y. (2023). Nanomaterials, 13(6), 1064. Read this article
This study utilized a low‑cost hydrothermal method to synthesize gallium oxide hydroxide (GaOOH) nanorods and adopted a high‑temperature annealing processes to develop nitrogen dioxide (NO2) gas sensors based on gallium oxide (Ga2O3) nanorods. To achieve a high surface‑to‑volume ratio of GaOOH nanorods, optimization methods were proposed in this study, including optimizing the thickness of the tin oxide (SnO2) seed layer and the precursor concentrations in the hydrothermal synthesis. In addition, GaOOH nanorods could cause dehydrogenation through annealing process to transform into Ga2O3 nanorods and increased the amount of oxygen vacancy. The optimal surface‑to‑volume ratio of GaOOH nanorods was obtained by using a 50 nm seed layer and a precursor concentration ratio of Ga(NO3)3·9H2O/HMT of 12 mM/10 mM in the hydrothermal synthesis. Furthermore, the NO2 gas sensors with 400 °C‑annealed Ga2O3 nanorod sensing membranes exhibited excellent gas sensing performance. The responsivity was 1184.6 % and response and recovery times were 63.6 s and 135.7 s, respectively, under a NO2 concentration of 10 ppm. The sensor was capable of detecting NO2 concentration as low as 100 ppb, with a responsivity of 34.2 %. Due to its low‑cost production and excellent sensing performance, Ga2O3 nanorods hold great potential for applications in NO2 gas sensors.
本研究利用低成本水熱法合成氫氧氧鎵(GaOOH)奈米柱並進行熱退火處理以開發氧化鎵(Ga2O3)奈米柱之二氧化氮(NO2)氣體感測器。為了實現高比表面積的氫氧氧鎵奈米柱，本研究提出之優化方式包括氧化錫(SnO2)晶種層的厚度調整以及水熱合成法之前驅物濃度最佳化。此外，研究證實GaOOH奈米柱可以通過熱退火製程使其進行脫氫反應以轉化為氧化鎵奈米柱，並增加其氧空缺含量。研究結果顯示，使用50 nm之晶種層與Ga(NO3)3·9H2O/HMT濃度為12 mM/10 mM之水熱合成法前驅物濃度比，可獲得最佳比表面積氫氧氧鎵奈米柱。此外，氧化鎵奈米柱經400 ℃熱退火處理後所製備而成之二氧化氮氣體感測器具有最佳的特性，在10 ppm的二氧化氮濃度下，其響應度為1184.6％，響應時間為63.6秒，恢復時間為135.7秒，並且可以檢測最低為100 ppb的二氧化氮濃度，其響應度為34.2％，表現出優秀的氣體感測性能。因此，由於其低成本生產和優異的感測性能，氧化鎵奈米柱在二氧化氮氣體感測器中具有極高的應用前景。
2. WiFi‑Based Detection of Human Subtle Motion for Health Applications.
Chen, H.-H., Lin, C.-L., & Chang, C.-H. (2023). Bioengineering, 10(2), 228. Read this article
Neurodegenerative diseases like Parkinson's affect motor functions, resulting in abnormal movements. These symptoms, including tremors and hand movement disorders, can be subtle and vary daily, making evaluating the disease during a short clinical session challenging. To address the issue, this study presents an approach for detecting human micromotion using Wi‑Fi channel state information, enabling home health monitoring and examination in regular‑sized rooms. The proposed method was tested on three types of motion, and the results demonstrated that micromotion could be accurately captured at multiple locations within the experimental environment. The computer algorithm achieved an average accuracy of 90.9 % (single Wi‑Fi link) to 95.7 % (multiple Wi‑Fi links) in computing the frequency and duration of simulated hand tremors.
神經退化性疾病，如巴金森病，會影響動作功能，導致運動異常。這些症狀包括顫抖和手部運動障礙等，在每日生活中細微起伏，亦隨著藥效波動產生變化，故醫師在短暫問診中要準確評估病況有其挑戰性。為解決此問題，本研究提出了一種利用Wi‑Fi通道狀態信息監測微小手部動作的方法，能夠在常規大小的房間中進行居家健康監測。經由三種動作類型的測試，顯示本方法在實驗環境中的各個位置上可準確捕捉到微小動作。本研究開發的電腦演算法在偵測模擬手部顫抖的頻率和持續時間的平均準確率為90.9％（單一Wi‑Fi收發對）至95.7％（多個Wi‑Fi收發對）。
3. Thinking more wisely: using the Socratic method to develop critical thinking skills amongst healthcare students.
Ho, Y.-R., Chen, B.-Y., & Li, C.-M. (2023). BMC Medical Education, 23(1), 173. Read this article
In medicine, critical thinking is required for managing and tolerating medical uncertainty, as well as solving professional problems and treating diseases. However, the core of Confucianism, teacher‑centered and exam‑oriented settings in middle and high school education may pose challenges to developing critical thinking in Han Chinese or Taiwanese students. Thus, how to guide students with less stable foundations of critical thinking might require more approach. Almost all healthcare students must complete a biochemistry laboratory course as part of their basic science training. Thus, we aimed to train students to develop critical thinking in the biochemistry laboratory course by using learning sheets and teacher guidance based on the Socratic method and questioning. We recruited second‑year students from a medical college, of whom 32 had medical science and biotechnology majors (MSB), 27 had pharmaceutical science majors (PS), and 85 were medical undergraduate (MU) students. Clarity and logic dimensions were identified as the key elements to facilitate the development of critical thinking skills through learning sheets and teacher guidance in students across all three different healthcare majors. The results showed that metacognitive monitoring via Socratic questioning learning sheets have demonstrated potential encourage students to develop critical thinking skills in all dimensions. Another unique contribution of current study was present the heterogeneous learning patterns and progress trajectories of clarity and logic dimensions within classes.
批判性思考是臨床上面對醫學的不確定性，甚至專業問題解決與疾病的診治都需要的技能。然而依據儒家的思維，以教師為中心、考試導向的初中和高中教育環境下，對華人或台灣學生批判性思維的發展確是挑戰。本研究目的在藉由蘇格拉底方法與提問理論，於生化實驗課程中，透過學習單設計和教師引導，培養學生的批判性思考技能。研究對象包括醫技(32人)、藥學(27人)、醫學(85人)。透過蘇格拉底式提問的學習單並進行後設認知的監測分析，顯示此模式可有效地提升學生批判性思考各個面向的表現。其中清晰度和邏輯面相是所有科系學生的關鍵要素。此外研究另一個重要貢獻是提出了異質性學習模式的成果，以及各班級清晰度與邏輯維度的進步軌跡。
4. Funneling of Oblique Incident Light through Subwavelength Metallic Slits.
Chen, A. E., Xia, X.-Q., Hong, J.-S., & Chen, K.-R. (2023). Nanomaterials, 13(1), 61. Read this article
Light funneling determines how enhanced energy flows into subwavelength slits. In contrast to the previous research on oblique incident light, this study reveals that light funneling in the slits can be highly asymmetric, even at small angles. This mechanism is explained by polarized fields and charges, which are induced using Poynting vectors. It is shown that when light is obliquely incident to the slits perforated in a perfect electric conductor, asymmetrical fields and charges accumulate at the upper apex corners of the left (right) sides. When light is incident from the left (right) side, more (less) induced fields and charges accumulate in the left (right) slit corner so that the funneling width, area, and energy flow at the left (right) side increases (decreases).
光漏斗效應決定了增強能量如何流入次波長狹縫。這項研究揭示了狹縫中的光漏斗在小角度入射下可能是高度不對稱的。這種機制可以通過極化場和電荷以及波印廷向量來解釋。結果顯示，當光線斜向入射完美導體中的狹縫時，不對稱的極化電荷分別累積在左（右）邊的轉角上。當光從左側入射時，會有較多（較少）的電荷累積在左（右）邊 狹縫的轉角，因此左（右）邊的漏斗寬度、面積和能量流增加（減少）。
5. Reversibility of some oxidative stress markers in chronic hepatitis C patients after receiving direct‑acting antiviral agents.
Cheng, P.-N., Sun, H.-Y., Feng, I. C., Wang, S.-T., Chiu, Y.-C., Chiu, H.-C., Chien, S.-C., & Young, K.-C. (2023). Journal of Virus Eradication, 9(1), 100318. Read this article
Introduction: Hepatitis C (HCV) is associated with extra‑hepatic involvment, morbidity as well as metabolic changes. Whether these might be reversible if sustained virologic response (SVR) is achieved by direct‑acting antiviral (DAA) therapy remains unknown. Methods: Chronic hepatitis C (CHC) individuals receiving DAA treatment with SVR were compared to those who underwent spontaneous clearance (SC) of HCV infection at the 2‑year follow‑up. Plasma oxidative stress markers (oxidized low‑density lipoprotein (oxLDL), 8‑hydroxy‑2′‑deoxyguanosine (8‑OHdG), malondialdehyde (MDA) and ischemia‑modified albumin (IMA)) as well as progression of liver fibrosis were evaluated. Results: Compared to SC individuals, those in the CHC group exhibited at baseline higher levels of oxLDL, 8‑OHdG and IMA but not of MDA. In the SC group, 8‑OHdG levels were elevated at 2‑year post‑SVR (p = 0.0409), while the DAA‑treated CHC group showed decrease in oxLDL (p < 0.0001) and 8‑OHdG (p = 0.0255) levels, approaching those of the SC group, but increased MDA (p = 0.0055) levels. Additionally, oxLDL levels were positively correlated with liver stiffness measurements at SVR (p = 0.017) and at 1 year post‑SVR (p = 0.002). Conclusions: Plasma oxLDL showed post‑SVR normalization after clearance of HCV viremia with DAAs and was associated with levels of hepatic fibrosis.
研究背景: C型肝炎與肝外受累及代謝變化有關。這些變化是否能藉由直接抗病毒藥物(DAA)療程治療達到持續性病毒反應(SVR)的情況下逆轉仍然未知。研究方法: 比較接受DAA療程且達到SVR追蹤兩年的慢性C型肝炎病人與自發性清除C型肝炎病毒且追蹤兩年的自願者血漿中氧化壓力標誌物（氧化低密度脂蛋白 (oxLDL)、8‑羥基去氧鳥苷 (8‑OHdG)、丙二醛 (MDA) 和缺氧修飾白蛋白 (IMA)以及肝纖維化的進展。研究結果: 與SC組別相比，在CHC 組別中的個體在未接受DAA治療時oxLDL、8‑OHdG 和 IMA有更高的表現量；但MDA表現並無差異。在 SC 組別中，8‑OHdG 表現量在 SVR 2 年後有升高的趨勢 (p = 0.0409)，而 接受DAA 治療的 CHC 組別中顯示 oxLDL (p < 0.0001) 和 8‑OHdG (p = 0.0255) 的表現量下降，且表現量與SC 組相近，但增MDA (p = 0.0055) 的表現量增加。此外，oxLDL 表現量與 SVR (p = 0.017) 和 SVR 1 年後 (p = 0.002) 的肝臟硬度測量值呈正相關。研究結論: DAAs清除 HCV 病毒血症後，血漿 oxLDL 的表現量在 SVR 後呈現正常表現且和肝纖維化水平相關。
6. A Modified 1H‑NMR Quantification Method of Ephedrine Alkaloids in Ephedrae Herba Samples.
Li, Y.-C., Wu, C.-H., Le, T. H., Yuan, Q., Huang, L., Chen, G.-F., Yang, M.-L., Lam, S.-H., Hung, H.-Y., Sun, H., Wu, Y.-H., Kuo, P.-C., & Wu, T.-S. (2023). International Journal of Molecular Sciences, 24(14), 11272. Read this article
A previous 1H‑NMR method allowed the quantification of ephedrine alkaloids; however, there were some disadvantages. The cyclized derivatives resulted from the impurities of diethyl ether were identified and benzene was selected as the better extraction solvent. The locations of ephedrine alkaloids were confirmed with 2D NMR. Therefore, a specific 1H‑NMR method has been modified for the quantification of ephedrine alkaloids. Accordingly, twenty Ephedrae Herba samples could be classified into three classes: (I) E. sinica‑like species; (II) E. intermedia‑like species; (III) others (lower alkaloid contents). The results indicated that ephedrine and pseudoephedrine are the major alkaloids in Ephedra plants, but the concentrations vary greatly determined by the plant species and the collection locations.
之前已報導的1H‑NMR方法可以對麻黃類生物鹼進行定量，然而仍然存在一些缺點。本研究對因乙醚的雜質而產生的環化衍生物進行了鑑定，改用苯作為較佳的萃取溶劑，並通過2D NMR的使用確認了各個麻黃類生物鹼的位置。因而修改所得的1H‑NMR方法對麻黃類生物鹼的定量更具有專一性。利用此方法分析收集到的20個麻黃樣品，依其結果可分為三類：（一）類草麻黃物種；（二）類中麻黃物種；（三）其他（低生物鹼含量）。結果表明，麻黃鹼和偽麻黃鹼是麻黃屬植物中的主要生物鹼，但其濃度因植物種類和採集地點的不同而存在較大差異。
7. Paper‑Based Exosomal MicroRNA‑21 Detection for Wound Monitoring: A Proof of Concept and Clinical Validation Trial Study.
Pan, S.-C., Lai, C.-H., Vu, V.-T., Vu, C.-A., Huang, C.-J., Cheng, C.-M., & Chen, W.-Y. (2023). International Journal of Molecular Sciences, 24(14), 9822. Read this article
Emerging evidence has shown that microRNAs play pivotal roles in wound healing. Exosomal miRNAs have been identified and explored as essential markers for diagnostic medicine. However, the role of exosomal miR‑21 in wounds has yet to be well studied. We developed an easy‑to‑use, rapid, paper‑based microfluidic‑exosomal miR‑21 extraction device to determine wound prognosis. We isolated and then quantitatively examined exosomal miR‑21 in wound fluids. Eight improving wounds displayed lower levels of exosomal miR‑21 expression after wound debridement. However, four instances of increased exosomal miR‑21 expression levels were notably associated with patients with poor healing wounds despite aggressive wound debridement, indicating a predictive role of tissue exosomal miR‑21 for wound outcome. Paper‑based nucleic acid extraction device provides a rapid and user‑friendly approach for evaluating exosomal miR‑21 in wound fluids as a means of monitoring wounds. Our data suggest that tissue exosomal miR‑21 is a reliable marker for determining current wound status.
利用外泌體小分子核糖核酸21型來預測傷口的預後已知資料顯示小分子核糖核酸在傷口癒合扮演重要的角色，外泌體中的小分子核糖核酸已知可利用來診斷疾病的嚴重度。然而，目前尚不清楚小分子核糖核酸21型在傷口扮演何種角色。我們研發一種紙基微流體外泌體小分子核糖核酸21型的分離器，這個方法可快速分離傷口中的外泌體小分子核糖核酸21型，利用這樣的方式可預測傷口的預後。結果顯示8個癒合良好傷口的外泌體小分子核糖核酸21型較低，4個癒合差的傷口外泌體小分子核糖核酸21型較高，證實外泌體小分子核糖核酸21型可用來預測傷口的預後。
8. Effect of morphologies and compositions of silver‑based multicomponent heterogeneous nanocrystals on the reduction of 4‑nitrophenol.
Huang, M.-S., Cheng, H.-T., & Hsu, S.-W. (2023). Nanoscale Advances. Read this article
Silver‑based nanocrystals have excellent catalytic performance in various reactions, such as the reduction of 4‑nitrophenol. The catalytic performance of nanocrystals varies with serval parameters, including nanocrystal morphology, composition, and plasmoninduced hot electrons around nanocrystals. Here, highly heterogeneous nanocrystals (Au‑Ag and Ag2S‑Ag nanocrystals) fabricated on polymer films via seed‑mediated are used as catalysts for the reduction of 4‑nitrophenol, and the effect of the morphology and composition of nanocrystals on the catalytic performance is investigated. These nanocrystals on polymer films exhibit higher reusability (low catalysts loss) in catalytic applications compared to catalysts dispersed freely in the reaction solution. The excellent catalyst performance of these heterogeneous nanocrystals is attributed to their high surface area/volume ratio (flower‑like nanocrystal) and strong synergistic effect (cage‑like nanocrystals). These nanocrystals with special morphologies and composites showed higher catalytic performance (higher reactivity at lower catalysts contents) than silver‑based nanocrystals reported in the literature. Due to the excellent plasmonic properties of Ag nanocrystals, the catalytic performance of these nanocrystals can be further enhanced by generating hot electrons around the nanocrystals under irradiation. These results demonstrated that by carefully controlling the morphology and composition of nanocrystals, it is possible to design and fabricate excellent catalysts for various reactions.
銀基奈米晶體在各種反應中具有優異的催化性能，例如 4‑硝基苯酚的還原。奈米 晶體的催化性能隨一些參數的變化而變化，包括奈米晶體形態、組成和奈米晶 體周圍電漿子誘導的熱電子。這裡，通過晶種介導在高分子薄膜上製備的高度非 均質奈米晶體（Au‑Ag 和 Ag2S‑Ag 奈米晶體）用作 4‑硝基苯酚還原之觸媒，並對 奈米晶體的形態和組成對催化性能進行研究。 與自由分散在反應溶液中的 觸媒相比，固定於高分子薄膜上的奈米晶體做為觸媒中表現出更高的可再使用 性（低觸媒回收損失率）。 這些非均質奈米晶體優異的催化劑性可歸因於它們的 高表面積/體積比（花狀奈米晶體）和強的協同效應（籠狀奈米晶體）。 這些奈米晶體與文獻報導的銀基奈米晶體表現出極高的催化性能，且其性能可在外照光源下使奈米晶體周圍產生熱電子來進一步增強催化性能。 這些結果表明通過仔細控制奈米晶體的形態和組成，可以設計和製造出用於各種反應的優異觸媒。
9. Bioengineered Bacteriophage‑Like Nanoparticles as RNAi Therapeutics to Enhance Radiotherapy against Glioblastomas.
Pang, H.-H., Huang, C.-Y., Chen, P.-Y., Li, N.-S., Hsu, Y.-P., Wu, J.-K., Fan, H.-F., Wei, K.-C., & Yang, H.-W. (2023). ACS Nano, 17(11), 10407‑10422. Read this article
Glioblastomas (GBMs) often resist radiotherapy, with many recurring post‑treatment. Enhancing radiotherapy via gene‑silencing has thus gained interest. However, challenges in consistent RNA loading in nanoparticles hinder clinical application. We've bioengineered bacteriophage particles with a three‑way junction (b‑3WJ) RNA scaffold for targeting radioresistant GBM genes. In vitro, the b‑3WJ RNA cleavage by Dicer enzyme is trackable via fluorescence microscopy. Moreover, TrQβ@b‑3WJ effectively silences both EGFR and IKKα genes, inhibiting the NF‑κB pathway and DNA repair. Utilizing convection‑enhanced delivery (CED) for TrQβ@b‑3WJ, followed by 2 Gy X‑ray, the median survival extended to over 60 days, compared to just 31 days in the standard 2 Gy X‑ray group. This highlights RNAi‑based strategies' potential and CED's efficacy in enhancing radiotherapy for GBMs without systemic toxicity.
由於膠質母細胞瘤 (GBMs) 常常對放射治療產生抗性，許多病患在化療及放射治療後仍常復發。因此，透過基因沉默來增強放射治療引起了眾多關注。然而，精確調控奈米顆粒中的組成與 RNA 裝載量的困難性導致 RNA 治療產品之間存在批次間變異，這大大限制了其在臨床的應用轉化。在本研究中，我們對噬菌體顆粒進行生物基因工程修改，設計了一種三向接頭 (b‑3WJ) RNA骨架，該骨架包含兩個 siRNA/miRNA 序列和一個發光適體，用於靜默放射抗性 GBM 細胞中的基因以降低 GBM 細胞放射抗性。體外試驗結果顯示，使用螢光顯微鏡可實時監測由 Dicer 酶對新設計的 b‑3WJ RNA 的切割情況，且 TrQβ@b‑3WJ 可同時有效靜默了 EGFR 和 IKKα 基因，進而抑制了 NF‑κB 信號傳導途徑，降低 DNA 的修復能力。透過對流增強遞送 (CED) 方式投遞 TrQβ@b‑3WJ，隨後進行 2Gy 的低劑量 X 射線照射，結果顯示與僅接受 2Gy X 射線照射的對照組相比，中位生存時間延長到超過 60 天 (對照組中位生存期：31天)。總之，這項研究的結果對於RNAi為基礎的遺傳治療策略設計具有關鍵意義，而CED技術作為一種有效的藥物遞送系統，有助於增強對 GBM 的放療效果並且大幅降低全身性毒性。
10. Stick‑slip squirmers: slip asymmetry can qualitatively change self‑swimming characteristics of squirmers.
Yang, F.-L., Chen, Y.-A., Premlata, A. R., & Wei, H.-H. (2023). Journal of Fluid Mechanics, 967, A29, Article A29. Read this article
A stick‑slip asymmetry can break the symmetry of the local hydrodynamic force distribution on the surface of an otherwise no‑slip or uniform‑slip particle. Here we use the Lorentz reciprocal theorem to demonstrate that such asymmetry, even in a small amount, can completely change the swimming characteristics of a self‑propelled spherical squirmer, making its behavior markedly different than a no‑slip or uniform‑slip squirmer. We find that the swimming velocity U of a stick‑slip squirmer can be driven alone by a symmetric extensile/contractile squirming from the B2 mode that commonly provides a stresslet, capable of reversing the swimming direction of the squirmer. A symmetric force dipole, namely stresslet S, can also be generated solely by a unidirectional diverging and converging squirming from the B1 mode that provides the thrust for the swimming, which can invert the stresslet of the squirmer from extensile type to contractile type or vice versa. When these two squirming modes are executing together, both U and S can be enhanced or diminished due to the interplays between asymmetric squirming forces generated by these two modes, depending on the stick‑slip partition and orientation. These distinctive features arising from stick‑slip asymmetry can not only be made geometrically tunable for steering the motion of a squirmer, but also provide new means for making efficient artificial microswimmers using catalytic Janus particles.
黏滑不對稱性可以破壞無滑移或均勻滑移粒子表面上的局部流體力學受力分佈的對稱性。我們使用洛倫茨互易定理來證明，即使是微小的黏滑不對稱性也可以完全改變球形自滑粒子的自泳動特性，使其表徵與無滑移或均勻滑移的自滑粒子明顯不同。我們發現，黏滑自滑粒子的泳動速度 U 可單獨由慣常提供應力子的 B2 模式的對稱伸展/收縮方式來驅動，該模式能夠反轉自泳動方向。而對稱的力偶，即應力子 S，也可以僅通過提供泳動所需推力的單向滑游B1模式來生成，可以將自滑粒子的應力子從伸展型轉變為收縮型，反之亦然。當這兩種自滑模式一起執行時，由於這兩種模式產生的不對稱滑泳力之間的相互作用，U 和 S 可能增強或減弱。由黏滑不對稱性引起的這些獨特性質不僅可藉幾何方式調控自泳動粒子的運動，還可能為使用兩面催化粒子製備高效的人工微米自游動機帶來新的方案。 |
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NCKU 成功大學-圖書館 |
(國立成功大學-圖書館)
2022年獲得圖書館OA補助文章之介紹
1. Agreement Between Caregivers’ Concerns of Children’s Developmental Problems and Professional Identification in Taiwan.
Lin, L.-Y., Yu, W.-H., Lin, W.-P., Chen, C.-C., & Tu, Y.-F. (2022). Frontiers in Pediatrics, 10 Read this article
Early detection of developmental delays relies on the accuracy of the caregivers’ concerns of children’s developmental problems. The aim of this study was to investigate the agreement between the caregivers’ awareness of children’s developmental problems and professional identification. Caregivers of 1963 children (age range: 5–71 months; mean: 38.4 months) younger than 6 years old who were at risk of developmental delays and referred to the center for a comprehensive evaluation were enrolled in this study. The caregivers’ initial concerns of cognitive, speech/language, emotional/behavioral, motor and global development showed low agreement with the results of professional identification. The major disagreement was observed in the cognitive domain. Speech/language developmental concern was an important red‑flag indicator of cognitive and emotional/behavioral developmental delays. The comorbid presence of ID, ASD, and ADHD was high in this study. Child’s age and mothers’ level of education were significant indicators for detecting the child’s developmental problems. It is recommended that assessing the cognitive developmental status is essential for all children in the identification process. Practitioners should not overlook caregivers' concern about speech/language and emotional/behavioral development. Transdisciplinary practitioners provide educational guidance to caregivers, especially in the domains of cognitive, speech/language, and emotional/behavioral development.
早期發現兒童發展遲緩取決於照顧者對兒童發展問題關注的準確性。本研究的目的是調查照顧者對兒童發展問題的認識與專業評估結果之間的一致性。本研究招募了1963名6歲以下兒童（年齡範圍：5-71個月；平均：38.4個月）的照顧者，這些兒童因發展遲緩的風險被轉介到中心進行全面評估。照顧者對兒童的認知、語言、情緒/行為、動作和整體發展遲緩問題的關注與專業鑑定結果的一致性較低，尤其是認知領域的一致性最低。語言發展問題是認知和情緒/行為發展遲緩的重要危險信號。研究中發現有很高的比率同時伴隨智能障礙、自閉症和注意力不足過動症的共病。兒童的年齡和母親的教育程度是檢測孩子發展問題的重要指標。建議在鑑定過程中評估所有兒童的認知發展狀態是不可少的。臨床工作者不應忽視照顧者對語言和情緒/行為發展的關注。跨領域專業人員需要為照顧者提供衛教資訊，特別是在認知、語言和情緒/行為發展領域。
2. Development and validation of a web-based prediction tool on minor physical anomalies for schizophrenia.
Wang, X.-Y., Lin, J.-J., Lu, M.-K., Jang, F.-L., Tseng, H.-H., Chen, P.-S., Chen, P.-F., Chang, W.-H., Huang, C.-C., Lu, K.-M., Tan, H.-P., & Lin, S.-H. (2022). Schizophrenia, 8(1), 4 Read this article
Minor physical anomalies (MPAs) have been suggested as biomarkers and potential pathophysiological significance for schizophrenia. However, an integrated, clinically useful tool that used qualitative and quantitative MPAs to visualize and predict schizophrenia risk while characterizing the degree of importance of MPA items was lacking. We recruited a training set and a validation set to conduct logistic regression and Lasso regression to select the best parameters of MPAs and constructed nomograms. Two nomograms were built to show the weights of these predictors. The results of the validation dataset verified the efficacy of the nomograms with the area under the curve 0.84 and 0.85 in the logistic regression model and lasso regression model, respectively. This study provides an easy‑to‑use tool based on validated risk models of schizophrenia and reflects a divergence in development between schizophrenia patients and healthy controls (https://www.szprediction.net/).
在過往研究中細微體質特徵被認為是思覺失調症的生物標記，且有其潛在病理生理意義。然而，臨床缺乏用於測量思覺失調症風險的質性和量性細微體質特徵之整合工具。我們使用邏輯斯迴歸和Lasso迴歸來選擇最佳參數以nomogram視覺化方式來預測思覺失調症之風險。驗證數據集結果的兩種迴歸模型中曲線下面積分別為 0.84 和 0.85。本研究反應了思覺失調症患者與健康對照組的發展差異，並提供一種基於驗證思覺失調症風險模型的便利使用工具 (https://www.szprediction.net/)。
3. Chemical Constituents of Hedyotis diffusa and Their Anti‑Inflammatory Bioactivities.
Hung, H.-Y., Cheng, K.-C., Kuo, P.-C., Chen, I.-T., Li, Y.-C., Hwang, T.-L., Lam, S.-H., & Wu, T.-S. (2022). Antioxidants, 11(2), 335 Read this article
Seven new anthraquinones with rare 2‑isopropyldihydrofuran (1–3) and 2,2‑dimethylpyrano (4–7) moieties together with thirty‑four known compounds were isolated from the extracts of whole Hedyotis diffusa plants. Their structures were elucidated and established by various spectroscopic and spectrometric analytical methods. Among these isolates, selected compounds were examined for their anti‑inflammatory activity. The results showed that rare substituted anthraquinones displayed potent inhibitory activity with IC50 values ranging from 0.15 ± 0.01 to 5.52 ± 1.59 µM on the N‑formyl‑methionyl‑leucyl‑phenylalanine/cytochalasin B (fMLP/CB)‑induced superoxide anion generation and elastase release cellular models. Meanwhile, the proposed drug target of the active anthraquinone was studied by computer modeling. The binding affinity between the anti‑inflammatory anthraquinone and elastase was evaluated by molecular docking. These results provided the scientific insight into the medicinal values of Hedyotis diffusa and vision of development as lead compounds. (Abstract, Antioxidants, 2022, 11(2), 335)
白花蛇舌草為常用的清熱解毒中草藥，本研究自全株植物之乙醇提取物中分離到41個天然化合物，其中新化合物1‑3具有少見的2‑isopropyldihydrofuran蒽醌骨架，而新化合物4‑7具有2,2‑dimethylpyrano蒽醌骨架，經由各種化學光譜和光譜分析方法對其結構進行了詳細的闡明和建立。在這些化合物中，篩選部分化合物進行抗發炎活性檢測，蒽醌類化合物對fMLP/CB誘導的超氧陰離子生成和彈性蛋白酶釋放具有很好的抑制活性，IC50 範圍在0.15 ± 0.01 ~ 5.52 ± 1.59 µM。同時，通過電腦模擬軟體，分子對接的方法研究抗發炎蒽醌與彈性蛋白酶的結合親和力推測。本研究結果為白花蛇舌草的藥用價值和蒽醌先導化合物的開發提供了部分科學依據。
4. Incidence of Voice Disorders among Private School Teachers in Taiwan: A Nationwide Longitudinal Study.
Chen, B.-L., Cheng, Y.-Y., Lin, C.-Y., & Guo, H.-R. (2022). International Journal of Environmental Research and Public Health, 19(3), 1130 Read this article
Teachers are more likely to use a loud voice at work than the general working population, but few longitudinal studies have been conducted on their risk of voice disorders. The occurrence of voice disorders in private school teachers was assessed by using the Longitudinal Health Insurance Database 2000 of Taiwan. This study included private school teachers who were under 35 years old and newly employed between 2000 and 2010, and used workers with other occupations as the comparison cohort. After adjusting for age, sex, income, and comorbidities of sinusitis and laryngitis, private school teachers had a higher risk of developing voice disorders (hazard ratio [HR] = 1.58; 95% confidence intervals: 1.43–1.75). In addition, the finding that elementary and highschool teachers had a higher risk than college teachers (HR: 2.56 vs. 1.44) and the pattern of increases in cumulative incidence over time. The results support the causality between occupation and voice disorders in teachers.
教師是聲帶疾患高風險族群，但較少縱貫性研究佐證。本研究利用台灣健保資料庫2000年版的百萬歸人檔，篩選出2000年至2010年間年齡少於35歲的新進私立學校教師，觀察他們的聲帶疾患發生情形，並與其他整體職業族群相對照。在校正年齡、性別、收入以及鼻竇炎、喉炎後，發現私校教師有較高罹患聲帶疾病風險(相對風險1.58，95%信賴區間1.43~1.75)，且中小學較大專院校教師有更高風險(相對風險分別為2.56和1.44)，暗示較長授課時數與管教需求的教師有更高的風險，進一步確立教師工作與聲帶疾患的因果關係。
5. Association of retinopathy severity with cardiovascular and renal outcomes in patients with type 1 diabetes: a multi‑state modeling analysis.
Wang, W.-M., Ou, H.-T., Wen, M.-J., Su, P.-F., Yang, C.-Y., Kuo, T.-H., Wang, M.-C., & Lin, W.-H. (2022). Scientific Reports, 12(1), 4177 Read this article
This study aimed to assess the impact of diabetic retinopathy (DR) severity on the incidence of major adverse cardiac events (MACE) and end‑stage renal disease (ESRD) in T1D patients. Patients diagnosed with T1D between 1999 and 2013 were identified from patient‑level data of Taiwan’s National Health Insurance Research database. A total of 1135 patients were included and classified into mild DR (n = 454), severe DR (n = 227), or non‑DR (n = 454) by using propensity score matching. Multi‑state model analyses, an extension of competing risk models with adjustment for transition‑specific covariates for prediction of subsequent MACE and ESRD, were performed. MACE and ESRD risks were significantly higher in the severe DR patients; a 2.97‑fold (1.73, 5.07) and 12.29‑fold (6.50, 23.23) increase in the MACE risk among the severe DR patients compared to the mild DR and DR‑free patients, respectively; and, a 5.91‑fold (3.50, 9.99) and 82.31‑fold (29.07, 233.04) greater ESRD risk of severe DR patients than that of the mild DR and DR‑free groups, respectively (p < 0.001). Severity of DR was significantly associated with the late diabetes‑related vascular events (i.e., MACE, ESRD) among T1D patients.
本研究目的在評估糖尿病視網膜病變 (DR) 嚴重程度對第一型糖尿病患者(T1D)患者主要不良心臟事件 (MACE) 和末期腎病變 (ESRD) 發生率的影響。研究對象為從台灣國民健康保險研究資料庫收錄1999年至2013年間被診斷患有T1D的病人，總共納入1135例患者，通過傾向評分匹配分為輕度DR（n = 454）、重度DR（n = 227）或無DR的對照組（n = 454）。進行了多狀態模型分析，本分析方式為競爭風險模型的擴展，並調整了特定過渡的協同變項，以預測隨後的MACE和ESRD。嚴重DR患者的MACE和ESRD風險顯著升高；與輕度DR和無DR患者相比，嚴重DR患者的MACE風險分別增加 2.97倍（1.73、5.07）和12.29倍（6.50、23.23）；並且嚴重DR患者的ESRD風險分別比輕度DR組和無DR組高5.91倍（3.50, 9.99）和82.31倍（29.07, 233.04）（p < 0.001）。DR的嚴重程度與T1D患者的晚期糖尿病相關血管事件（即MACE和ESRD）顯著相關。
6. Ge/Si multilayer epitaxy and removal of dislocations from Ge‑nanosheet‑channel MOSFETs.
Chu, C.-L., Chang, J.-Y., Chen, P.-Y., Wang, P.-Y., Hsu, S.-H., & Chou, D. (2022). Scientific Reports, 12(1), 959 Read this article
Horizontally stacked pure‑Ge‑nanosheet gate‑all‑around field‑effect transistors were developed in this study. Large lattice mismatch Ge/Si multilayers were intentionally grown as the starting material rather than Ge/GeSi multilayers to acquire the benefits of the considerable difference in material properties of Ge and Si for realising selective etching. Additionally, dislocations were observed in suspended Ge nanosheets because of the absence of a Ge/Si interface and the disappearance of the dislocation‑line tension force owing to the elongation of misfit dislocation at the interface. Forming gas annealing of the suspended Ge nanosheets resulted in a significant increase in the glide force compared to the dislocation‑line tension force; the dislocations were easily removed because of this condition and the small size of the nanosheets. Based on this structure, a new mechanism of dislocation removal from suspended Ge nanosheet structures by annealing was described, which resulted in the structures exhibiting excellent gate control and electrical properties.
本研究目標乃開發一個水平堆疊的純鍺納米片柵環場效應晶體管。以大晶格錯位的Ge/Si多層作為起始材料，而非多層之Ge/GeSi。透過利用Ge和Si的材料性質有很大差異的好處，以實現選擇性蝕刻之目的。此外，由於沒有 Ge/Si 界面，並且於界面處錯位的拉申，使位錯線張力消失。與位錯線張力相比，懸浮鍺納米片的形成氣體退火導致滑動力顯著增加；由於這種條件和納米片的小尺寸，位錯很容易去除。基於這種結構，描述了一種通過退火從懸浮的鍺納米片結構中去除錯位的新機制，從而使結構表現出優異的柵極控制和電學性能。
7. Effects of symmetry breaking of the structurally‑disordered Hamiltonian ensembles on the anisotropic decoherence of qubits.
Chen, H.-B. (2022). Scientific Reports, 12(1), 2869 Read this article
Hamiltonian ensemble (HE) is a novel approach to investigate the incoherent dynamical processes of quantum systems. It is particularly versatile in locally detecting bipartite quantum correlations and the characterization of the process nonclassicality. The HE theory is, in principle, applicable to very general unital dynamics; however, due to the technical difficulty imposed by the non‑abelian algebraic structure underlying the HE, the results are exemplified under the frameworks of pure dephasing or isotropic depolarization. In this work, I achieve to circumvent the algebraic difficulty and go further beyond the aforementioned two frameworks, reaching the regime of anisotropic decoherence. A new type of HE of structural disorder in canonical form is studied. The disorder is categorized according to different levels of symmetry of its geometry. I have demonstrated four levels of symmetry, from the most symmetric case of spherical symmetry to the discrete type of simultaneous reflectional symmetries. This enables us to clearly distinguish how the different incoherent dynamical behaviors are caused by various types of symmetry breaking. These results significantly enhance the applicability the HE‑simulation of open quantum systems.
哈密頓量系綜集合表示法是近年來新發展起來的工具，可用來研究量子系統的消相干動力學過程。當應用這個方法在局部地偵測量子關聯性、描述與量化消相干動力學過程中展現出的非古典性時又特別的有用。儘管本方法理論上可以廣泛應用在各類型的消相干動力學過程中，然而，由於本方法其內在的非阿貝爾代數結構之故，使得其廣泛應用性會遇到許多數學上的困難，致使目前大多數的工作僅用其來描述特定簡化類型的動力學過程，如純消相位過程或各向均勻去極化過程。在本工作中，我們成功克服一些數學代數結構方面的困難，突破以往的研究限制框架，達到各向非均勻去極化過程。因此這裡可以研究一種新類型的哈密頓量系綜集合，我們稱之為結構性的無序。這類結構性的無序可根據其無序分布的對稱性而加以有條理的分類與研究，讓我們可以了解不同的消相干行為是由甚麼類型的對稱性破缺引起。這些研究成果使的哈密頓量系綜集合理論的應用性可以更加廣泛。
8. Hyperuricemia Is Associated with Significant Liver Fibrosis in Subjects with Nonalcoholic Fatty Liver Disease, but Not in Subjects without It.
Yen, P.-C., Chou, Y.-T., Li, C.-H., Sun, Z.-J., Wu, C.-H., Chang, Y.-F., Lu, F.-H., Yang, Y.-C., Chang, C.-J., & Wu, J.-S. (2022). Journal of Clinical Medicine, 11(5), 1445 Read this article
Liver fibrosis is associated with liver‑related outcomes, yet often underdiagnosed in the primary care settings. Hyperuricemia is associated with non‑alcoholic fatty liver disease (NAFLD), but the relationship between hyperuricemia and liver fibrosis remains unclear. Data on individuals without NAFLD is also limited. We investigated the association between hyperuricemia and liver fibrosis in subjects with and without NAFLD. This study recruited 11,690 relevant participants from a health‑checkup center. Hyperuricemia was positively associated with significant liver fibrosis (p = 0.001) in the logistic regression. The positive association of hyperuricemia with significant liver fibrosis remained in subjects with NAFLD (p = 0.001), but not in subjects without NAFLD.
肝纖維化與肝相關的結果相關，但在基層醫療卻時常被忽略。高尿酸血症與非酒精性脂肪肝(NAFLD)有關，但與肝纖維化的關係仍未明。過去研究資料在沒有NAFLD的族群者資料有限。本篇研究探討在有無NAFLD的病人，其高尿酸血症及肝纖維化的相關性。此篇收錄11690位至健康檢查中心、符合收錄條件的成年人。經過邏輯式迴歸，高尿酸血症與顯著肝纖維化成正相關(p = 0.001)，且其正相關僅見於有NAFLD的族群，而不見於無NAFLD的族群。
9. VLSI Architecture of S‑Box With High Area Efficiency Based on Composite Field Arithmetic.
Teng, Y. T., Chin, W. L., Chang, D. K., Chen, P. Y., & Chen, P. W. (2022). IEEE Access 10, 2721‑2728 Read this article
This work aims at optimizing the hardware implementation of the SubBytes and inverse SubBytes operations in the advanced encryption standard (AES). To this, the composite field arithmetic (CFA) is employed to optimize all building blocks in S‑box (and inverse S‑box) of SubBytes (and inverse SubBytes) transformation. A joint design of S‑box and inverse S‑box is also proposed to further enhance the area efficiency. Specifically, the area of multiplier in the Galois composite field, GF((22)2), is reduced. The squaring and multiplication with constant λ in GF((22)2) are combined and optimized as well. Moreover, the multiplicative inversion in GF((22)2) is manually optimized. Furthermore, the S‑box and inverse S‑box are combined and optimized using the pre_processing and post_processing modules. To increase the throughput, a balanced and pipelined architecture is derived. Using the proposed architecture, a throughput of 5.79 Gbps for the S‑box can be achieved on Virtex‑6 XC6VLX240T and 10% better than the conventional work. According to the ASIC implementation result, the proposed design can still achieve the highest area efficiency and approximately 30% better than conventional works using TSMC 90nm process.
這項工作旨在優化高級加密標準 (AES) 中SubBytes和反SubBytes操作的硬件實現。為此，採用複合域算法（CFA）優化SubBytes（和逆SubBytes）變換的S盒（和逆S盒）中的所有構建塊。還提出了S盒和逆S盒的聯合設計，以進一步提高面積效率。具體來說，伽羅瓦複合域中乘數的面積GF((22)2)減少了。 GF((22)2)中常數λ的平方和乘法也被組合和優化。此外，GF((22)2)中的乘法反元素是手動優化的。此外，使用 pre_processing 和 post_processing 模塊對S盒和逆S盒進行組合和優化。為了增加吞吐量，衍生出一種平衡的流水線架構。使用所提出的架構，S盒的吞吐量可以在 Virtex‑6 XC6VLX240T 上實現 5.79 Gbps，比傳統工作高 10%。根據 ASIC 的實現結果，所提出的設計仍然可以達到最高的面積效率，並且比使用台積電 90nm 工藝的傳統作品好約 30%。
10. Spatiotemporal Dynamics of Cerebral Vascular Permeability in Type 2 Diabetes‑Related Cerebral Microangiopathy.
Chen, Y.-C., Lu, B.-Z., Shu, Y.-C., & Sun, Y.-T. (2022). Frontiers in Endocrinology, 12.2721‑2728 Read this article
Aims: Diabetes‑related cerebral microangiopathy can manifest as cerebral small vessel disease (CSVD) and exhibit cognitive decline. To find the early change of function in advance, this study examined the spatiotemporal dynamics of cerebral vascular permeability (Ktrans) in the progression of type 2 diabetes mellitus (T2DM). Methods: Ktrans was crossectional measured in T2DM and non‑diabetes groups with or without CSVD using dynamic contrast‑enhanced MRI (DCE‑MRI). Results: In all patients with T2DM, the Ktrans of white matter (WM) was increased, whereas the Ktrans of gray matter (GM) was increased only in T2DM with CSVD. The involvement of WM was earlier than GM and was prior to the CSVD features could be visualized on MRI. Among the commonly available four CSVD items of MRI, microbleeds was most sensitive, indicating the increased permeability in all patients. Increased Ktrans in T2DM was more associated with moderate WM hyperintensity but less with the presence of lacunae or multiple perivascular spaces, in contrast to patients without diabetes. The differential correlation suggested distinct mechanisms underlying diabetes‑related CSVD and other CSVDs. Conclusions: This study highlights the early development of cerebral microangiopathy with increased BBB leakage in T2DM, prior to the CSVD features can be visualized on MRI. The results may increase the proactivity of clinicians in recognizing the subsequent neurological comorbidities.
背景：脫光體驗(IVC)在T2DM的進展中，腦血管通透性(Ktrans)的空間時間動態被檢測。結果：在所有T2DM患者，白質(Ktrans)增加，而灰質(Ktrans)僅在T2DM伴隨CSVD時增加。白質的參與早於灰質，且在MRI能視覺化CSVD特徵之前。常用的四項MRI CSVD指標中，微出血最為敏感，表明所有患者的通透性增加。T2DM中的Ktrans增加與中度白質高信號更相關，且與腦室缺失或多個血管間隙的存在較少相關，與非糖尿病患者不同。不同的相關性暗示了糖尿病相關CSVD和其他CSVD的不同機制。結論：本研究突顯了在T2DM中腦血管通透性增加導致腦微血管病變的早期發展，在MRI能視覺化CSVD特徵之前。結果可能促進臨床醫師對後續神經合併症的主動識別。 |
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1. Z-Complementary Code Sets With Flexible Lengths From Generalized Boolean Functions。
Wu, S. W., Şahin, A., Huang, Z. M., & Chen, C. Y. (2021). IEEE Access, 9, 4642-4652.
In the literature, most Z-complementary code set (ZCCS) constructions based on generalized Boolean functions lead to sequences of power-of-two length. In this study, we show that our proposed direct constructions result in ZCCSs of both power-of-two length and non-power-of-two length. Since the monomials of degrees more than 2 are employed in the proposed constructions, more ZCCSs can be obtained. The constructed ZCCSs admit the theoretical upper bound on the size for a ZCCS when the sequence length is a power of two. Also, the corresponding peak-to-average-power ratio (PAPR) is theoretically upper-bounded when a sequence in the set is used in OFDM. The proposed constructions extend the applications of ZCCSs in practical communication systems, e.g., multicarrier CDMA (MC-CDMA) system, by offering flexible sequence lengths, various set sizes, and bounded PAPR.
大部分文獻中採用布林函數來建構零相關區間互補集合的做法在序列長度上侷限於二的冪次方。而在此研究中，我們提出了全新的建構方法，涵蓋二冪次方以及非二冪次方長度，並能獲得更多的序列集合。此外，在二的冪次方長度下，所建構出的序列集合個數能夠滿足理論的最大值。並且，提出的序列集合擁有良好的尖峰平均功率比性質。
2. Anti-IL-20 Antibody Protects against Ischemia/Reperfusion-Impaired Myocardial Function through Modulation of Oxidative Injuries, Inflammation and Cardiac Remodeling。
Tsai, K.-L., Chou, W.-C., Cheng, H.-C., Huang, Y.-T., Chang, M.-S., & Chan, S.-H. (2021). Antioxidants, 10(2), 275.
We confirmed that IL-20 antibody injection at the moment of reperfusion reduces I/R-caused oxidative injuries, apoptosis, inflammation, as well as the elevation in markers of cardiac fibrosis and remodeling. We also proved that IL-20 antibody injection attenuates cardiac functional impairment, including the repressed EF and FS, the increased left ventricular end-diastolic and end-systolic volumes, and plasma markers of cardiac injury and heart failure. This study elucidates that IL-20 antibody might be favorable in lessening reperfusion injury in the treatment of AMI.
我們證明動物心肌缺血在再灌注時注射IL-20抗體可減少缺血/再灌注引起的氧化損傷，細胞凋亡，心肌發炎反應以及心臟纖維化和心臟重塑標誌物的升高。我們還證明了IL-20抗體注射可以減輕心臟功能損害，包括降低的左心室射出率，左心室收縮功能，左心室舒張末期和收縮末期容積的增加以及心臟損傷和心衰竭的血液標誌物。
3. The Spatial-Temporal Distribution of GOCI-Derived Suspended Sediment in Taiwan Coastal Water Induced by Typhoon Soudelor。
Chau, P. M., Wang, C.-K., & Huang, A.-T. (2021). Remote Sensing, 13(2), 194.
We use high temporal resolution Geostationary Ocean Color Imager (GOCI) to monitor the spatial–temporal distribution of suspended sediment (SS) along the coastal waters of northern Taiwan which was affected by Typhoon Soudelor from 8 to 10 August 2015. The results show that SS concentration increased during 11–14 August and then decreased during 19–22 August. The mouths of the Dajia River and Tamsui River were hotspots of SS, ranging from 9 to 15 g/m3, during the two post-typhoon periods. It is also shown that maximum SS occurred in the west and east coastal water during 11–14 August and 19–22 August, respectively. Furthermore, an exponential decay model was used to compute the time when 90% of typhoon-induced SS was dissipated after Typhoon Soudelor. It was found that the mouths of the Tamsui River and Heping River had the longest time, with a range of 360–480 h.
本文以高時間解析度GOCI衛星影像，觀測北台灣沿岸海水懸浮泥沙濃度（SS）受2015年8月蘇迪樂颱風影響之時空分佈。在颱風過後，SS分別於8月11–14日觀測期間上升，8月19–22日觀測期間下降，且大甲溪與淡水河之河口為高SS之熱區，達9–15 g/m3。以指數衰減模型計算減少90％颱風誘發的SS所需時間，發現淡水河與和平溪河口需要360–480小時。
4. An aptamer interacting with heat shock protein 70 shows therapeutic effects and prognostic ability in serous ovarian cancer。
Lin, C.-N., Tsai, Y.-C., Hsu, C.-C., Liang, Y.-L., Wu, Y.-Y., Kang, C.-Y., Lin, C.-H., Hsu, P.-H., Lee, G.-B., & Hsu, K.-F. (2021). Molecular Therapy – Nucleic Acids, 23, 757-768.
In this study, we aim to clarify the novel aptamer, Tx-01, clinical role and possible molecular mechanisms of Tx-01 in Ovarian cancer. Immunostaining and statistical analysis were performed to detect the interaction of Tx-01 and heat shock protein 70/Notch1 intracellular domain in OvCa. The in vitro and in vivo experiments demonstrated the potential mechanisms of Tx-01. Tx-01 reduced serous OvCa OVCAR3 cell migration and invasion and inhibited HSP70 nuclear translocation by interrupting the intracellular HSP70/NICD interaction. Furthermore, Tx-01 suppressed serous-type OVCAR3 cell tumor growth in vivo. Tx-01 acts as a prognostic factor through its interaction with membrane-bound HSP70 on ascetic circulating tumor cells and is reported to be involved in natural killer (NK) cell recognition and activation. Our data demonstrated that Tx-01 interacted with HSP70 and showed therapeutic and prognostic effects in serous OvCa. Tx-01 might be a potential inhibitor for use in serous OvCa treatment.
在這個研究中，我們發現新穎的適體TX-01跟HSP70在卵巢癌中有做結合。TX-01可以抑制卵巢癌OVCAR3細胞的移動及入侵, 同時抑制HSP70細胞核的移動 , 在小鼠上抑制OVCAR3的腫瘤生長。透過卵巢癌病人的腹水當中HSP70的結合, 可以作為治療預後的指標。因此我們認為TX-01的適體透過HSP70的結合可以在漿液性卵巢癌當中，具有作為治療以及預後預測的角色。
5. Diversified Phenomena in Metal- and Transition-Metal-Adsorbed Graphene Nanoribbons。
Lin, S.-Y., Tran, N. T. T., & Lin, M.-F. (2021). Nanomaterials, 11(3), 630.
In this study, the significant similarities and differences among Bi-/Al-/Ti-/Fe-/Co-/Ni-adsorbed graphene nanoribbons (GNRs) are thoroughly investigated by using the first-principles calculations. The main characterizations include the adsorption sites, bond lengths, stability, band structures, charge densities, spin- and orbital-projected density of states, and magnetic configurations. Furthermore, there exists a transformation from finite gap semiconducting to metallic behaviors, accompanied by the nonmagnetism, antiferromagnetism, or ferromagnetism. The proposed theoretical framework could be generalized to explore other emergent 1D and 2D materials.
使用第一原理計算，研究其Bi // Al- / Ti- / Fe- / Co- / Ni吸附的石墨烯奈米帶（GNR）之間的顯著差異。主要特徵為吸附位、鍵長、穩定性、能帶結構、電荷密度、自旋及軌道投影態密度與磁性構型。此外，伴隨著非磁性，反鐵磁性或鐵磁性，存在有限間隙半導體到金屬行為之轉變。此結果概括了理論性框架，及探索研究其它新興之1D與2D材料。
6. Nanomedicine-Based Strategies Assisting Photodynamic Therapy for Hypoxic Tumors: State-of-the-Art Approaches and Emerging Trends。
Shih, C.-Y., Wang, P.-T., Su, W.-C., Teng, H., & Huang, W.-L. (2021). Biomedicines, 9(2), 137.
Since the first clinical cancer treatment in 1978, photodynamic therapy (PDT) technologies have been largely improved and approved for clinical usage in various cancers. Due to the oxygen-dependent nature, the application of PDT is still limited by hypoxia in tumor tissues. Thus, the development of effective strategies for manipulating hypoxia and improving the effectiveness of PDT is one of the most important area in PDT field. Recently, emerging nanotechnology has benefitted progress in many areas, including PDT. In this review, we will discuss the state of the art of nanomedicine-based approaches for assisting PDT for treating hypoxic tumors, mainly based on oxygen replenishing and oxygen dependency diminishing strategies. We will emphasize emerging trends about the use of nanoscale metal–organic framework materials and the combination of PDT with immunotherapy. We further discuss future perspectives and challenges associated with these trends in both the aspects of mechanism and clinical translation.
使自首次臨床治療，光動力療法(PDT)有很大的進展並核准用於各種癌症。因對氧的依賴，PDT受腫瘤缺氧的限制，開發控制缺氧和提高療效的策略便成PDT重要方向。本文將討論奈米技術輔助PDT治療缺氧腫瘤的新進展，聚焦氧氣補充和減少氧氣依賴，強調使用奈米有機金屬及PDT與免疫療法結合的趨勢，最後總結相關機制的臨床轉化及其前景和挑戰。
7. Phage Digestion of a Bacterial Capsule Imparts Resistance to Two Antibiotic Agents。
Luo, C.-H., Hsu, Y.-H., Wu, W.-J., Chang, K.-C., & Yeh, C.-S. (2021). Microorganisms, 9(4), 794.
Bacteriophages are viruses that specifically infect bacteria, which have developed extraordinary proteins for recognizing and degrading their host. Inspired by the remarkable development of viral proteins, phage-derived proteins have been used for clinical treatment of multi-drug resistant (MDR) bacteria infection. For example, the polysaccharide depolymerase or endolysins were used to attenuate bacterial cell walls or to destroy the bacterial membrane. More recent efforts have addressed bacterial selection to treat drug-stress or phage infection. We, then, propose a combination strategy of co-treating MDR Acinetobacter baumannii with phage endolysin derived peptide and polysaccharide depolymerase (the tail fiber molecules). In the study, we surprisingly observed a temporary increase in resistance to colistin, used as the last-resort antibiotic for MDR Gram negative bacterial infection. Evaluation of the phage attacking behavior suggests the temporary increased resistance may be associated with an increased risk of drug‑resistance during phage‑antibiotic synergy in clinical MDR A. baumannii treatment.
噬菌體是感染細菌的病毒。以結構蛋白為靈感，衍生的蛋白質已成臨床治療多重抗藥細菌的選擇。以分解細胞壁的多聚醣酶，或溶裂細胞膜的內溶素為例，近期有抗藥則對蛋白易感的結論。本研究欲發展其藥用，卻意外發現多聚醣酶會增強細菌對最後一線抗生素-黏菌素的風險。對目前發展合併噬菌體與抗生素使用為一重要的警訊。
8. Computer-Assisted System in Stress Radiography for Anterior Cruciate Ligament Injury with Correspondent Evaluation of Relevant Diagnostic Factors。
Wang, C.-K., Lin, L.-C., Sun, Y.-N., Lai, C.-S., Chen, C.-H., & Kao, C.-Y. (2021). Diagnostics, 11(3), 419.
Retrospective research for 177 patients (129 with completely torn ACLs confirmed on magnetic resonance imaging) at our institution was performed. The anterior tibial translations with four different methods were measured by a computer-assisted system. Mean anterior tibial translations were significantly increased in the patients with a completely torn ACL, with diagnostic accuracies ranging from 66.7% to 75.1%. The diagnostic accuracy of method four was negatively associated with the time interval between stress radiography and MRI as well as force-joint distance on stress view, and not significantly associated with age, gender, flexion angle, intercondylar distance, and force-joint angle.
回朔性收集本機構177位患者(129位由磁振造影確認前十字韌帶斷裂)後，透過電腦輔助用四種方法測量前脛位移，前十字韌帶斷裂患者之平均前脛位移顯著增加，診斷率66.7%-75.1%。方法四之診斷率與時間間隔以及施力-關節距離呈負相關，與年齡、性別、曲折角、髁間距、施力-關節角無顯著相關。
9. Anti-Inflammatory Principles from the Needles of Pinus taiwanensis Hayata and In Silico Studies of Their Potential Anti-Aging Effects。
Kuo, P.-C., Li, Y.-C., Kusuma, A. M., Tzen, J. T. C., Hwang, T.-L., Ye, G.-H., Yang, M.-L., & Wang, S.-Y. (2021). Antioxidants, 10(4), 598.
Pinus needle tea, which is very popular in Eastern countries, is claimed to have significant anti-aging effects. In this study, five undescribed compounds as well as seventy-two known compounds were characterized from the methanol extracts of P. taiwanensis needles. Most of the isolates were examined for their anti-inflammatory bioactivity, and six compounds exhibited significant inhibitions on superoxide anion generation and elastase release. These ingredients were subjected to docking computing to evaluate their binding affinity on the ghrelin receptor to explore the potentials of anti-aging effect. Three tested compounds formed a stable complex with the ghrelin receptor via hydrogen bonds and different types of interactions, and it suggested these flavonoids to be responsible for the potential anti-aging effects of pine needle tea.
松針茶因宣稱有抗老化效果而廣受歡迎。本研究由台灣二葉松純化得到5個新化合物及72個已知化合物，其中6個對超氧陰離子與彈性蛋白酶具有抑制活性。利用對接模擬計算結合生長激素受體的能力，以觀察其抗老化活性潛力。結果顯示松針中的黃酮類化合物能與生長激素受體形成穩定的複合物，證明其具有抗發炎及抗老化之效果。
10. Electrosynthesized Ni‑P nanospheres with high activity and selectivity towards photoelectrochemical plastics reforming。
Lin, C.-Y., Huang, S.-C., Lin, Y.-G., Hsu, L.-C., & Yi, C.-T. (2021). Applied Catalysis B: Environmental, 296, 120351.
Photoelectrochemical reforming of plastic waste offers an environmentally‑benign and sustainable route for hydrogen generation. Nonetheless, little attention was paid to develop electrocatalysts that can efficiently and selectively catalyze oxidative transformation of valueless plastic wastes into valued chemicals. Herein, we report on facile electrosynthesis of nickel‑phosphorus nanospheres (nanoNi‑P), and their versatility in catalyzing hydrogen generation, water oxidation, and reforming of polyethylene terephthalate (PET). Notably, composite of nanoNi‑P with carbon nanotubes (CNT/nanoNi‑P) requires −180 mV overpotential to drive hydrogen generation at -100 mA cm−2. Besides, CV‑activated nanoNi‑P (nanoNi‑P(CV)) was shown to be capable of reforming PET into formate with high selectivity (Faradic efficiency= ~100 %). Efficient and selective generation of hydrogen and formate from PET reforming is realized utilizing an Earth‑abundant photoelectrochemical platform based on nanoNi‑P(CV)-modified TiO2 nanorods photoanode and CNT/nanoNi‑P cathode. This work paves a path for developing artificial leaf for simultaneous environmental mitigation and photosynthesis of renewable fuels and valued chemicals.
塑膠廢棄物的光電化學重整反應提供了一具環境友善且永續的產氫途徑。儘管如此，開發能夠有效和選擇性地將無價值的塑膠廢棄物氧化轉化成有價值的化學品的電觸媒卻很少受到關注。本研究中，我們開發了鎳磷奈米球的簡便電合成方法，以及它們在催化產氫、水氧化和聚對苯二甲酸乙二酯(PET)重整反應的多功能性。此外,我們也開發了鎳磷奈米球為基底的光電化學元件，實現光驅動聚PET重組生成甲酸與氫氣反應，達到整治環境與生成可再生燃料和高價值化學品之目的。
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Medical Library, Information Desk (886)6-2353535 Ext. 5120、6710
**About**
The Interlibrary Loan Service provided by the NCKU Library is a resource sharing service that allows eligible users to request items not available in the University Library. It is available to eligible users on a cost‑recovery basis.
**Eligible User**
Current NCKU faculty, students and staff; Alumni with a valid NCKU Alumni Library Card (limited to RapidILL service).
**Service Interface**
The Library provides interlibrary loan service through the following two systems. You may choose according to your needs.
*RapidILL Express Document Delivery Service*
RAPID is an organization of libraries mainly from universities in the United States dedicated to fast and cost‑effective resource sharing. Request for photocopies of materials submitted through RapidILL service will be delivered often within 24 hours. If a patron needs photocopies of materials written in western languages, a request through RapidILL is preferable.
Services provided are: Photocopies of Journal Articles & Book Chapters.
Charges: NT$3 per page without a processing fee.
*Nationwide Document Delivery Service (NDDS)*
An online request system that provides book loan and photocopies of materials services to all participating libraries in Taiwan. First‑time users should register first before using the system.
Services provided are:
- Photocopies of Journal Articles & Book Chapters
- Dissertations & Theses
- Fast Document Delivery Service among 7 Universities (NCKU library cooperates with National Sun Yat‑sen University, National Chung Cheng University, National Chung Hsing University, National Yang‑ming Chiao‑Tung University, National Chengchi University, and the Kaohsiung Medical University to provide fast interlibrary copying services. The copying fee is NT$3 per page without a processing fee. The turnaround time is about 3 working days, but most schools will fill the request on the same day.)
- Book Loans.
Charges:
- Domestic Borrowing: Fees vary depending on the lending library. Most libraries charge NT$5 per page plus a NT$20 processing fee for copies. Most libraries charge NT$100 per request plus NT$70 return postage for loans.
- International Borrowing: NT$450 per request for copies; NT$800 per request plus return postage for loans.
Above mentioned prices are the standard fee of most libraries for your reference only, as fee policies vary among libraries.
**Copyright Notice**
Users are obliged to comply with relevant copyright law while utilizing the materials provided by the interlibrary loan office of National Cheng Kung University library. The photocopies or reproductions are only for research, study or private use and not for any commercial purpose. For more details about copyright law, please refer to the page of Propagation of IPRs.
**Related Information**
Photocopies of Library Held Journal Articles; Interlibrary Loan Promo; Frequently Asked Questions (Q & A).
**Service Policy**
National Cheng Kung University Libray Inter‑library Cooperation Service Operation Regulations. |
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NCKU-National Cheng Kung University Library |
(以下為國立成功大學圖書館的網頁內容)
Contact：Main Library, Information Desk on 3F｜(886)6-2757575 Ext. 65741、65735｜Medical Library, Circulation Desk｜(886)6-2353535 Ext. 5120
About Express Document Delivery Service (via RapidILL)
- How to login？ How to cancel request？
About Nationalwide Document Delivery Service (NDDS)
- What do I do if I forgot my password？ What do I do if my account is cancelled or overdue？ What do I do if I can not register？ What is the fastest and most economical way to request materials from other libraries？ How to cancel requests？ How do I choose between RapidILL and NDDS？
Others
- What is RapidILL？ What is NDDS？ What is Union Catalog？
Q：How to login to Express Document Delivery Service（via RapidILL）？
A：請選擇「RapidILL」於圖書館首頁，然後以教職員/學生/校友圖書館卡號與密碼登入。無需額外註冊。
Q：How to cancel requests？
A：取消請求須依圖書館政策辦理，請撥打圖書館人員協助。Main Library電話：(886)6-2757575 ext. 65734(NDDS)、65735(RapidILL)；Medical Library電話：(886)6-2353535 ext. 5120。
Q：What do I do if I forgot my NDDS password？
A：請前往NDDS（Nationwide Document Delivery Service）並點選「check password」，輸入您的身分證字號並送出，系統將以電子郵件方式發送密碼。您亦可選擇以電話聯絡圖書館人員：Main Library電話：(886)6-2757575 ext. 65734；Medical Library電話：(886)6-2353535 ext. 5120。
Q：What do I do if my account is cancelled or overdue？
A：請聯絡圖書館人員協助：Main Library電話：(886)6-2757575 ext. 65734；Medical Library電話：(886)6-2353535 ext. 5120。
Q：What do I do if I can not register NDDS？
A：請聯絡圖書館人員協助：Main Library電話：(886)6-2757575 ext. 65734；Medical Library電話：(886)6-2353535 ext. 5120。
Q：What is the fastest and most economical way to request materials from other libraries？
A：第一，檢查NCKU圖書館目錄與E-Resource，確定所需物品在館內無缺。第二，依照書籍或期刊類型檢查聯合目錄或其他圖書館目錄，並選擇持有所需物品之圖書館。第三，盡可能填入多家借閱圖書館，系統若第一家失敗將自動轉交下一家。NCKU已與NSYSU、CCU、NCHU、KMU、NCCU、NYCU合作提供快速服務，複印 NT$3/頁，書籍借閱 NT$100/本（外加 NT$70 費）且無任何服務費。
Q：How do I choose between RapidILL and NDDS？
A：對於西方語言材料的複印，請使用 RapidILL。對於非西方語言材料或書籍借閱，請使用 NDDS。
Q：What is RapidILL？
A：RAPIDILL，由科羅拉多州立大學摩根圖書館開發，為美國大學圖書館組成的快速、經濟資源共享組織。透過 RapidILL 提交的複印請求可於 24 小時內完成。
Q：What is NDDS？
A：NDDS（Nationwide Document Delivery Service）為台灣本土發展的圖書館資源共享系統，採收費方式，費用因圖書館而異。首次使用者需註冊登入。
Q：What are Union Catalogs？
A：聯合目錄為結合兩個或以上圖書館目錄之資料庫，使用者可搜尋多圖書館藏書並透過 ILL 借閱書籍或取得文章複印。部分聯合目錄資料不完整，建議使用者搜尋更多目錄以確保能找到所需資料。
List of Union Catalogs：
Union Catalogs for Periodicals：Union List of Serials（由 STPI、NARL 提供），MetaCat + integrated inter‑library system（由國立臺灣大學圖書館提供）。
Union Catalogs for Books：National Bibliographic Information Network (NBINET)（由國立中央圖書館提供），MetaCat + integrated inter‑library system（由國立臺灣大學圖書館提供）。 |
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NCKU 成功大學-圖書館 |
(國立成功大學圖書館)
服務諮詢：總圖書館三樓服務臺 06-2757575 轉 65741、65735；醫學院圖書分館服務臺 06-2353535 轉 5120。
RapidILL 西文文獻快遞服務使用問題：
Q：如何登入 RapidILL 西文文獻快遞服務？西文文獻快遞服務提供本校在職/學教職員工生及持有效圖書館校友借書證者申請。請於圖書館首頁點選 RapidILL 後進入，於登入畫面輸入帳號及密碼後即可登入。本介面使用之帳號/密碼與個人圖書館借閱查詢之帳號/密碼相同，無需再另外申請帳號。
Q：如何取消申請件？讀者提出申請件後若欲取消，請直接以電話與總館（ext. 65734、65735）或醫分館（ext. 5120）館際合作業務人員聯絡，告知申請編號。圖書館尚未送出之申請件可馬上取消，已送出之申請件則視對方處理進度，未處理者可退件處理，已處理則無法取消，仍需繳款取件。
NDDS 系統使用問題：
Q：進入 NDDS 系統的密碼忘記了，怎麼辦？進入全國文獻傳遞服務系統，點選密碼查詢即可，系統會將密碼 e‑mail 至信箱，或與圖書館聯繫，電話：總圖（06）2757575 ext. 65734；醫分館（06）2353535 ext. 5120。
Q：帳號取消或過期如何處理？請與圖書館聯繫，電話：總圖（06）2757575 ext. 65734；醫分館（06）2353535 ext. 5120。
Q：我在成大是第一次申請 NDDS 系統，但系統顯示 ID（身份證號重覆）無法註冊成功？NDDS 是全國學術單位共同使用的系統，每人僅能註冊一組帳號。如曾在其他單位註冊過，請連絡原註冊單位將帳號刪除，才能重新註冊並選擇本校。
Q：透過 NDDS 向外館申請資料時，如何快又省？1. 請先查詢本館館藏、電子資源查詢系統，許多資料在館內紙本或電子館藏即可取得全文，避免外求，自行影印即快又經濟。2. 如確定館內無需之資料，再查詢圖書或期刊聯合目錄。3. 填寫申請單時，盡量填滿被申請單位，方便轉件（第一個單位無法處理時，系統自動轉至下個單位執行，避免退件）。4. 成大與中山、中正、中興、高醫、政大、陽明交大等六校提供彼此讀者館際合作快速服務，影印每頁 3 元；圖書互借 100 元（另加回郵郵資 70 元），影印免收服務費，速度快又省費，請多利用。
Q：如何選擇透過 RapidILL 或 NDDS 申請？若是申請西文文獻複印，可優先選擇透過 RapidILL 系統申請；其他語文資料複印或圖書借閱，請透過 NDDS 系統申請。
名詞解釋：
Q：什麼是 RapidILL？RapidILL 西文文獻快遞服務為美國 Colorado State University 之 Morgan Library 館合部門自行研發之館際文獻複印系統；會員多以美國地區大學圖書館為主。該系統會自動找出有館藏的合作圖書館，讀者不需先查詢聯合目錄與挑選申請館；RapidILL 要求會員需於 24 小時內處理申請件，並以電子傳輸方式傳送至申請館，顯著提高文獻複印申請效率。
Q：什麼是 NDDS？NDDS 為全國文獻傳遞服務系統之英文縮寫，由國研院科技政策中心所營運維護，為國內圖書館提供線上申請複印全文資料及圖書借閱之平台。第一次使用者需先註冊。
Q：什麼是聯合目錄？聯合目錄是一種包含兩個或以上圖書館館藏之書目資料庫，讀者可一次檢索多館館藏資料訊息，並以館際合作服務申請借書或影印資料全文。由於資料量龐大，部分聯合目錄內容不完整，建議搜尋多個不同聯合目錄系統。
常用的聯合目錄：
期刊聯合目錄：全國期刊聯合目錄資料庫（科政中心提供）、MetaCat + 即時跨館整合查詢館藏服務（台大圖書館提供）。
圖書聯合目錄：全國圖書書目資訊網 NBINET（國家圖書館提供）、MetaCat + 即時跨館整合查詢館藏服務（台大圖書館提供）。 |
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NCKU-National Cheng Kung University Library |
(以下為國立成功大學圖書館的網頁內容)，
聯絡方式：主館資訊櫃 3F (886)6-2757575 分機 65741、65735；醫學圖書館流通櫃 (886)6-2353535 分機 5120、5148；電子郵件 ill@libmail.lib.ncku.edu.tw、ndds@libmail.lib.ncku.edu.tw。
登入系統：NDDS（Nationwide Document Delivery Service）。
申請清單：首次使用者須於系統註冊，完成後將於兩個工作天內收到登入許可信；請先查閱線上圖書館目錄及 E-Resources Gateway 確認該項目未被持有或無法取得；查閱 MetaCat+整合館際系統或 NBINET，選擇持有所需項目的圖書館；填寫申請表並上傳，若台灣內無持有圖書，則可向海外圖書館申請館際互借；當所需項目收到時，我們會以電郵通知，並將其放於選定之圖書館（主館或醫學圖書館）待取；於截止日期前還書。
費用：國內借閱：根據借出圖書館不同，費用大約 NT$100 借閱費及 NT$70 回郵郵資；國際借閱：NT$800 借閱費加空郵回郵郵資，並將超過標準費用之海外館際互借費用全額轉給使用者，並事先徵得同意。
交付時間：國內館際互借 3-7 天；國際館際互借 10-30 天，視各館作業日程而定。
借閱期限：國內館際互借按借出館之借閱期限為主，通常在 3 週（含配送時間）內，且不提供續借；國際館際互借按借出館之期限為主，可續借。 |
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| 8464 |
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NCKU 成功大學-圖書館 |
(以下為國立成功大學圖書館的網頁內容)，
服務諮詢：總圖書館三樓服務臺 06-2757575 轉 65741、65735；醫學院圖書分館服務臺 06-2353535 轉 5120、5148。
使用系統：全國文獻傳遞服務系統（NDDS：Nationwide Document Delivery Service）。
申請方式：第一次使用此系統者，請先申請讀者帳號，待一至二個工作天，圖書館將 E‑mail 核准使用通知，收到通知後，即可啟用該系統；先查詢本館館藏目錄及電子資源查詢系統，確認本館無法提供所需之資料；透過 MetaCat + 即時跨館整合查詢館藏服務或全國圖書書目資訊網 NBINET，查詢確認有典藏您所需圖書的單位；線上填寫借書申請單並送出，若國內圖書館均無館藏，則請提出國外館合借書申請；收到 E‑mail 取件通知後請至原申請單位（總圖3F或醫分館服務櫃台）繳款取書；於到期日前，將該書歸還至取書地點。
收費標準：國內館合，依各館收費標準而定，大多數圖書館收費每本100元並加收70元寄回郵資；國外館合，每件800元並加收寄回航空掛號郵資；上述價格僅供參考；但因各單位收費不定，若超過上述費用，本館會與申請者另行連繫確認。
處理速度：國內約需3-7天時間，視各單位作業情況而定；國外約需10~30天不等，視各單位作業情況而定。
借期：國內圖書館，依借方館規定，多為三週（包含郵寄時間），不得續借；國外圖書館，依借方館規定。 |
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| 8465 |
https://www.lib.ncku.edu.tw/se... |
NCKU-National Cheng Kung University Library |
(以下為國立成功大學圖書館的網頁內容)
Contact: Main Library, Information Desk on 3F｜(886)6-2757575 Ext. 65741、65735｜Medical Library, Circulation Desk｜(886)6-2353535 Ext. 5120、5148
Login System: NDDS（Nationwide Document Delivery Service）
Application Checklist: First time users should register before using the system. We will notify you by email within 2 working days for the approval to login the system. NCKU dissertations or theses held by the Library can be found using the online Library Catalog by an Author or Title search. Print copies are located at the Theses & Dissertation area on the 5th floor of the library. Thesis & dissertation in electronic format can be downloaded from the E-Thesys Dissertation System under the author’s authorization and without invading the copyright law. Dissertations & Theses of other universities, including overseas universities, may be found in full text using the Library's subscription dissertations & theses databases on the NCKU E-Rescources Gatway. For those cannot be found in full text, you may want to place ILL requests. Login to the NDDS and fill in the request form online. For Dissertations and theses from institutions outside Taiwan, please apply for an international interlibrary loan. We will notify you by email when the item has been received, and it will be kept in the library you selected（Main Library or Medical Library）for you to pick up.
Charges: Domestic Theses & Dissertations: Charges vary by library. Most libraries charge NT$5 per page; some also charge an additional transaction fee. Photocopies made between the NCKU and the NSYSU, CCU, NCCU, NCTU, and KMU are charged NT$3 per page without transaction fee. Foreign Theses & Dissertations: Charges vary by library. We will always check with patrons first before proceeding with the request. Requests sent to the Science and Technology Policy Research and Information Center will be charged accordingly. Titles found in the ProQuest Dissertations and Theses (PQDT) may be purchased directly from the site as PDF format or printed copies.
Turnaround Time: National ILL: 1-7 days. International ILL: 14-30 days, depending on each library’s working schedule. |
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| 8466 |
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NCKU 成功大學-圖書館 |
(國立成功大學圖書館)
服務諮詢：總圖書館三樓服務臺 06-2757575 轉 65741、65735；醫學院圖書分館服務臺 06-2353535 轉 5120、5148。
使用系統：全國文獻傳遞服務系統（NDDS：Nationwide Document Delivery Service）。
申請方式：第一次使用此系統者，請先申請讀者帳號，待一至二個工作天，圖書館將 E-mail 核准使用通知，收到通知後，即可使用該系統。 本校論文可利用圖書館館藏目錄以作者名或論文名稱查詢。紙本論文放置於總圖五樓論文專區，依系所分開陳列；電子全文則請連線電子學位論文服務系統，在作者授權及不違反著作權原則下，逕行下載全文。 其他國內外學校的博碩士論文，請連線本館電子資源查詢系統，利用本館採購之學位論文資料庫查詢，逕行下載全文。 無全文可下載者，請登入全國文獻傳遞服務系統提出博碩士論文複印或借閱申請。申請複印請填妥【博碩/研究報告複印】申請單；若為國內論文，建議將研究生的畢業學校填在第一個被申請單位，第二個填國家圖書館；國外論文則請提出國外館合申請並請註明畢業學校名稱。 收到 E-mail 取件通知後請至原申請單位（總圖1F或醫分館櫃台）繳款取件。
收費標準：國內論文：依各館收費標準而定（大多數圖書館收費每頁 5 元，部分加收服務費）。 成大與中山、中正、中興、交大、政大、高醫等七校間館際複印，每頁 3 元；不收服務費。 國外論文：透過本館向國外單位申請者，依對方定價收費。 透過科資中心申請者，詳細費用請參考國研院科技政策研究與資訊中心收費標準。 ProQuest Dissertations and Theses (PQDT)博碩士論文資料庫中收錄的論文，讀者亦可自行在線上訂購並選擇傳真、郵寄或直接下載 PDF 檔案。
處理速度：國內：約需 1-7 天不等，視各單位作業情況及傳遞方式而定。 國外：約需 14~30 天不等，視各單位作業情況及傳遞方式而定。 |
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| 8467 |
https://www.lib.ncku.edu.tw/se... |
NCKU-National Cheng Kung University Library |
(以下為國立成功大學圖書館的網頁內容)
Contact：Main Library, Information Desk on 3F (886)6-2757575 Ext. 65741、65735；Medical Library, Circulation Desk (886)6-2353535 Ext. 5120、5148
Login System：NDDS（Nationwide Document Delivery Service）
Application：First time users should register before using the system；Please check online Library Catalog and E-Resources Gateway first to see that the item is not held or unavailable from the Library；Check MetaCat + intergrated inter‑library system or Union List of Serials and NBINET, and select the libraries which hold the required item；Fill in the request form and send it online；If the required item is not held by any libraries in Taiwan, you may place ILL requests to overseas libraries；We will notify you by email when the item has been received, and it will be kept in the library you selected (Main Library or Medical Library) for you to pick up
Charges：Domestic Borrowing：Fees vary depending on the lending library；Most libraries charge NT$5 per page plus a NT$20 processing fee；Photocopies made between the NCKU, NSYSU, CCU, NCHU, NYCU, NCCU and KMU are charged NT$3 per page without processing fee；International Borrowing：NT$450 per request；For Medical Library, requests are sent to the U.S. National Library of Medicine through Docline；We will pass on to patrons the full cost of charges for interlibrary loans from overseas that are higher than the standard charges, but we will always check with patrons first before proceeding
Turnaround Time：National ILL：1-7 days；International ILL：3-15 days, depending on each library’s working schedule；Requests sent to the U.S. National Library of Medicine are received mostly within 24 hours on a business day |
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| 8468 |
https://www.lib.ncku.edu.tw/se... |
NCKU 成功大學-圖書館 |
(國立成功大學圖書館) 服務諮詢：總圖書館三樓服務臺 06-2757575 轉 65741、65735；醫學院圖書分館服務臺 06-2353535 轉 5120、5148。
使用系統：全國文獻傳遞服務系統（NDDS：Nationwide Document Delivery Service）。
申請方式：第一次使用此系統者，請先申請讀者帳號，待一至二個工作天，圖書館將 E‑mail 核准使用通知，收到通知後，即可使用註冊之帳密登入該系統；請先查詢本館館藏目錄及電子資源查詢系統，確認本館無法提供所需之資料；透過 MetaCat + 即時跨館整合查詢館藏服務或全國期刊聯合目錄資料庫及全國圖書書目資訊網 NBINET，查詢確認有典藏您所需資料的單位；線上填寫文獻複印申請單並送出，若國內圖書館均無該資料，則請提出國外館合複印申請；收到 E‑mail 取件通知後請至原申請單位（總圖1F或醫分館櫃台）繳款取件。
收費標準：國內館合依各館收費標準而定。大多數圖書館收費每頁 5 元並加收 20 元服務費；成大與中山、中正、中興、陽明交大、政大、高醫等七校間館際複印，每頁 3 元；不收服務費。國外館合每件 450 元；醫分館國外館合單位僅限美國國家醫學圖書館；上述價格為標準收費，但因各單位收費不一，若超過上述費用，本館會與申請者另行連繫確認。
處理速度：國內館合約需 1‑7 天不等，視各單位作業情況及傳遞方式而定；國外館合約需 3‑15 天不等，視各單位作業情況及傳遞方式而定；醫分館西文文獻僅限向美國國家醫學圖書館申請，除例假日外，通常於隔天即可收件。
申請注意事項：請先查詢本館館藏目錄及電子資源查詢系統，凡本館有館藏者，可自行下載、影印或借閱；填寫國內複印申請單時，請多填寫幾個館藏單位，以便被申請單位無法提供時能迅速轉到下一單位；傳遞方式可選擇 Express，透過網路傳送文件，速度快，通常每頁 5 元，不加郵寄費；申請時限：大多數圖書館都會以最快的速度處理申請件，若必須設定申請時限，請勿設得太短，以免造成申請館因沒有把握在期限前提供而退件，反而耽誤取得文獻的時間，請留意。 |
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2026-01-04 00:28:51 |
| 8469 |
https://www.lib.ncku.edu.tw/se... |
NCKU-National Cheng Kung University Library |
(以下為國立成功大學圖書館的網頁內容)，
Contact: Main Library, ILL on 3F (886)6-2757575 Ext. 65735、65741; Medical Library, Circulation Desk (886)6-2353535 Ext. 5120、5148
RapidILL Express Document Delivery Service: RAPID is an organization of libraries mainly from the universities in the United States dedicated to fast and cost-effective resource sharing. Request for photocopies of materials submitted through RapidILL service will be delivered often within 24 hours. RAPIDILL now has members including libraries from North America, Europe, Asia, Australia and New Zealand.
Eligible User: Current NCKU faculty, students and staff; Alumni with a valid NCKU Alumni Library Card.
Application Checklist: Check online Library Catalog and E-Resource Gateway before ordering materials; Request through RapidILL; Login to the system with your Library ID Number and Password and fill out the request form; Provide a complete and accurate citation, fill in journal title in full (no abbreviations), provide an ISBN or ISSN number whenever possible; Library will notify you via email when your request arrives in the library, and it will be kept in the library you selected for pickup.
Charges: Requests filled by RapidILL will be charged NT$3 per page; Requests transferred to other domestic libraries via NDDS will be charged according to the supplying library; Items obtained from overseas libraries will be charged NT$450 per request, and the library will pass on the full cost of charges for interlibrary loans from overseas that are higher than the standard charges, but will always check with patrons first before proceeding.
Turnaround time: It takes 1 ~ 3 business days to fill the request through RapidILL, but most of them received within 24 hours; Requests transferred to other libraries through NDDS will take 1-14 business days.
Remarks: Requests for book loan and copies of Dissertations & Theses must be submitted through NDDS; For copies of materials written in Chinese and Japanese, please request first through NDDS. |
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2026-01-04 00:29:19 |
| 8470 |
https://www.lib.ncku.edu.tw/se... |
NCKU 成功大學-圖書館 |
(以下為國立成功大學圖書館的網頁內容)
服務諮詢：總圖書館三樓服務臺 06-2757575 轉 65735、65741，醫學院圖書分館服務臺 06-2353535 轉 5120、5148
說明：RapidILL是一個國際間的館際合作服務系統，主要以提供西文文獻複印服務為主，透過該服務讀者最快可於24小時內取得自家圖書館沒有蒐藏的文獻資料。RapidILL 的合作成員致力於提供快速有效的資源分享服務，主要以美國地區的大學圖書館為主，其他會員館則分布於北美洲、大洋洲及部分歐亞地區。
服務對象：本校教職員生、持有效圖書館校友借書證者
申請方式：透過本館 RapidILL 西文文獻快遞服務介面向 RAPID 提出申請。西文期刊、圖書、會議論文等篇章之文獻複印請優先使用此系統申請。請先查詢本館館藏目錄及電子資源查詢系統，確認本館無法提供所需之文獻。登入後即可填寫申請單提出申請，此介面使用之帳號/密碼與個人圖書館借閱查詢之帳號/密碼相同，無需再另外申請帳號。請提供詳細正確的書目資料以加快處理速度，期刊刊名請儘量以全名表示。收到E‑mail取件通知後請至當時選定之總圖或醫分館繳款取件。
收費標準：透過 RapidILL 取得之文獻，以每頁3元之價格收費。無法由RapidILL取得經讀者同意轉至 NDDS 系統申請之國內件，費用依各圖書館收費標準計價。轉國外館合之申請件，每篇450元；但因各單位收費不一，若超過上述費用，本館會與申請者另行連繫確認。
處理速度：透過 RapidILL 系統，約 1 ~ 3 個工作日（最快為24小時）可取件。無法透過 RapidILL 系統獲得而轉至國內外其他單位申請之文獻，則約需 3 ~ 14 個工作日，視提供單位處理狀況與傳遞方式而定。
注意事項：借書及博碩士學位論文複印，請透過 NDDS 全國文獻傳遞服務系統申請。中日語文文獻或國內出版品文獻的複印申請，請先透過 NDDS 全國文獻傳遞服務系統申請。 |
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2026-01-04 00:29:42 |
| 8471 |
https://www.lib.ncku.edu.tw/se... |
NCKU-National Cheng Kung University Library |
(以下為國立成功大學圖書館的網頁內容)
Origins：The SPARK位於主館一樓，為舉辦小型講座或工作坊的創意空間，設有24張可自由調整的模組化座椅及約20張分層座位，牆面全長設有白板，並配備投影電腦設備；當無活動時，對外開放閱讀，供圖書館讀者使用。
Application Guidelines：請於圖書館行政電子系統提交申請，並將活動計畫電郵至em65760@email.ncku.edu.tw。
Important Notice：1. 請閱讀國立成功大學圖書館場地使用管理規範； 2. 每場活動人數設定20至50人； 3. 可預約時間為上午9點至下午5點，每場時間最多4小時； 4. 預約可於6個月內使用，註冊須於使用日前至少7天完成； 5. 圖書館將審查申請並以電郵通知結果； 6. 借閱人或代表須於預定使用時間前20分鐘以有效圖書館證登記； 7. 取消須於活動日前7天前完成，逾期取消將被取消預約並依圖書館規定扣分； 8. 申請人必須親自或指派代表於預定使用日前7個工作日與圖書館負責人確認場地並於活動前一小時協助設備安裝及測試； 9. 產品推廣或商業行為之活動不接受申請； 10. 活動海報需事前經圖書館核准後張貼； 11. 內部禁止攜帶食物、飲料、違禁物品及寵物； 12. 內部請勿大聲喧嘩； 13. 請自行保管個人物品，圖書館不負責遺失，將於關館時移除； 14. 圖書館保留任何時間核查身分證明之權利，未持有效證件或偽造、變造、磁卡等者將立即離館並依圖書館場地使用管理規範處理； 15. 根據行政院文件1090201804A，2020年12月18日，禁止使用來自中國大陸製造的資訊與通訊產品。
Service Policy：National Cheng Kung University Library Guidelines for the Management of Venue Space of the Library. |
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2026-01-04 00:30:07 |
| 8472 |
https://www.lib.ncku.edu.tw/se... |
NCKU-National Cheng Kung University Library |
(以下為國立成功大學圖書館網頁內容)，
Contact：Library Extension Services｜06-2757575 Ext. 65793 or 65790
Service Objects：Academic, artistic, and cultural exhibitions or speeches approved by the Library
Service Hours：During the Library’s opening hours
Application Process：Please go to the University’s E‑campus Administrative Affair System to submit an application and email the activity plan to the Library. Applicants should complete the reservation registration two weeks to two months before the intended use. In case of scheduling conflicts with the events held by the University or Library, the University or Library shall have priority. Student clubs of the University applying to use this venue should submit the approved activity consent form or activity plan from the Office of Student Affairs Office of the University, and the same applies to changes. Before applying, please check the exhibition/event calendar and call the Library to confirm the available time slots.
Fees：For use by on-campus units or faculty/staff clubs, the principle is that no charge will be incurred. However, if fees are charged from participants or if there is external funding support, a venue usage fee should be paid. Student clubs of the University using the venue space should follow the relevant subsidy application procedures for venue usage fees outlined in the “National Cheng Kung University Directions for Subsidies for Funds for the Use of Assembly Venues by Student Self‑governing Organizations and Clubs of NCKU”. Charges are calculated in four‑hour units; for less than four hours, a four‑hour charge applies. Book shelf area, exhibition events only: on‑campus unit 1,500 NTD, off‑campus units 3,000 NTD. Platform in the center, lecture events: 1,000 NTD, off‑campus units 2,000 NTD. Platform in the center, exhibition events: 800 NTD, off‑campus units 1,600 NTD. Peg Wall area, exhibition events only: 1,500 NTD, off‑campus units 3,000 NTD. The full usage fee should be paid in one lump sum at least seven days before the date of use, or it will be deemed as giving up the reservation made. For any unit hosting events that require library staff attendance and support, such as lectures, workshops, film screenings, post‑screening discussions, book launches, etc., in venues other than the Conference Center during weekday evenings or on weekends, an additional fee of 1,000 NTD per session will be charged.
Note：1. The use of this venue space shall be handled in accordance with the “National Cheng Kung University Library Guidelines for the Management of Venue Space of the Library”. 2. The unit borrowing the venue should designate one dedicated personnel on‑site to communicate with the Library staff and be present intermittently during the exhibition and event period for supervision and inspection. 3. Setting up the venue or posting promotional materials should be carried out after obtaining prior approval from the Library. 4. Violation of any of the following may result in the immediate termination by the Library of the current venue usage rights: (1) The use of a destructive drilling method in venue setup that leads to damage to the Library’s original walls, floors, or other structures. (2) Unauthorized expansion of the exhibition area during setup, affecting pathways and rights of other readers. 5. Personal belongings, equipment, and materials should be properly guarded by designated personnel. The Library bears no responsibility for any loss or damage. 6. After the exhibition concludes, the dedicated on‑site personnel is responsible for conducting an inventory and returning the venue and all equipment and materials used to the Library’s staff (or administrators). Any dirt, garbage, waste, or items not belonging to the Library resulting from the venue’s use should be cleaned and removed on the same day, and the venue should be restored to its original condition. 7. Moving or installing various equipment and tools without prior permission from the Library is strictly prohibited. If improper use leads to damage or loss of facilities, it will be handled according to the “National Cheng Kung University Library Rules for Reader Violations”. 8. During the exhibition construction period, please minimize noise and avoid disturbing other readers. If improvement is not observed after being reminded, the borrowing rights for that unit will be terminated after the conclusion of the exhibition. 9. For events such as opening ceremonies, interviews, speeches, etc., please notify the Library in advance to facilitate the preparation of microphone equipment and the creation of activity sound notice boards for other readers. If not notified in advance, the Library reserves the right to safeguard reader rights and decline the holding of an opening ceremony. 10. Events involving food and beverages such as tea parties are not permitted in the LibRE. 11. If the applying unit is unable to use the venue, it should apply to the Library for the cancellation or postponement at least seven days before the reserved date. Applications not submitted within the deadline will not be accepted by the Library, except for cases where the inability to use the venue is due to natural disasters or force majeure. 12. In case of a violation of any circumstance outlined in Point 10 of the “National Cheng Kung University Library Guidelines for the Management of Venue Space of the Library”, the Library reserves the right to immediately terminate the applicant’s right to use the venue with no refund of fees. The applicant’s right to apply for borrowing the venue may be suspended for one year, and in severe cases, the matter may be reported to the University for further action or legal prosecution. 13. Adherence to the designated usage time is mandatory, and occupation of the venue beyond the scheduled time is prohibited. Extensions may be granted for special circumstances with the Library’s approval. 14. If the Library has an urgent need to use the reserved venue space, it may notify the borrowing unit at least 7 days prior to the reserved date to cancel the use and coordinate to re‑schedule a later date and time. If postponement is not possible, the Library shall refund the venue space usage fee paid by the borrowing unit without interest, and the applicant may not seek any other compensation or reimbursements. 15. The Library reserves the right for further review. Please call 06-2757575 Ext. #65793 or email to z10908064@ncku.edu.tw for any queries.
Guidelines：National Cheng Kung University Library Guidelines for the Management of Venue Space of the Library.
Application System：University’s E‑campus Administrative Affair System.
Relevant Information：National Cheng Kung University Library Rules for Reader Violations; Exhibition Schedule. |
embedded |
2026-01-04 00:30:45 |
| 8473 |
https://www.lib.ncku.edu.tw/se... |
NCKU-National Cheng Kung University Library |
(以下為國立成功大學圖書館的網頁內容)，Contact：Library Extension Services｜06-2757575 Ext. 65793 or 65790。Service Objects：Academic, artistic, and cultural speeches or exhibitions approved by the Library。Service Hours：During the Library’s opening hours。Application Process：Please go to the University’s E‑campus Administrative Affair System to submit an application and email the activity plan to the Library，Applicants should complete the reservation registration two weeks to two months before the intended use，In case of scheduling conflicts with the events held by the University or Library, the University or Library shall have priority，Student clubs of the University applying to use this venue should submit the approved activity consent form or activity plan from the Office of Student Affairs Office of the University, and the same applies to changes，Before applying, please check the exhibition/event calendar and call the Library to confirm the available time slots。Fees：For use by on‑campus units or faculty/staff clubs, the principle is that no charge will be incurred；if fees are charged from participants or if there is external funding support, a venue usage fee should be paid；Student clubs of the University using the venue space should follow the relevant subsidy application procedures for venue usage fees outlined in the “National Cheng Kung University Directions for Subsidies for Funds for the Use of Assembly Venues by Student Self‑governing Organizations and Clubs of NCKU”；Charges are calculated in four‑hour units，for less than four hours will be charged for four hours；For NCKU departments 1,000 NTD；for off‑campus units 2,000 NTD；For any unit hosting events that require library staff attendance and support, such as lectures, workshops, film screenings, post‑screening discussions, book launches, etc., during weekday evenings or on weekends, an additional fee of 1,000 NTD per session will be charged；The full usage fee should be paid in one lump sum at least seven days before the date of use，or it will be deemed as giving up the reservation made。Note：The use of this venue space shall be handled in accordance with the “National Cheng Kung University Library Guidelines for the Management of Venue Space of the Library”；The unit borrowing the venue should designate one dedicated personnel on‑site to communicate with the Library staff and be present intermittently during the exhibition and event period for supervision and inspection；Setting up the venue or posting promotional materials should be carried out after obtaining prior approval from the Library；Violation of any of the following may result in the immediate termination by the Library of the current venue usage rights：No nailing, gluing, or attaching of any objects, including promotional posters or instruction signs, is allowed on glass doors and windows，cement‑painted walls (including columns)，ceilings, and floors；Due to circuit issues, the lighting in the Multifunctional Area cannot be all turned on for an extended period；for longer‑term exhibitions, please choose lighting that complements the exhibition during the exhibition design；Personal belongings, equipment, and materials should be properly guarded by designated personnel；The Library bears no responsibility for any loss or damage；After the exhibition concludes, the dedicated on‑site personnel is responsible for conducting an inventory and returning the venue and all equipment and materials used to the Library’s staff (or administrators)，Any dirt, garbage, waste, or items not belonging to the Library resulting from the venue’s use should be cleaned and removed on the same day，and the venue should be restored to its original condition；Moving or installing various equipment and tools without prior permission from the Library is strictly prohibited；if improper use leads to damage or loss of facilities, it will be handled according to the “National Cheng Kung University Library Rules for Reader Violations”；Events involving food and beverages such as tea parties are not permitted in the Multifunctional Area；If the applying unit is unable to use the venue, it should apply to the Library for the cancellation or postponement at least seven days before the reserved date；applications not submitted within the deadline will not be accepted by the Library, except for cases where the inability to use the venue is due to natural disasters or force majeure；In case of a violation of any circumstance outlined in Point 10 of the “National Cheng Kung University Library Guidelines for the Management of Venue Space of the Library”，the Library reserves the right to immediately terminate the applicant’s right to use the venue with no refund of fees；the applicant’s right to apply for borrowing the venue may be suspended for one year，and in severe cases, the matter may be reported to the University for further action or legal prosecution；Adherence to the designated usage time is mandatory，and occupation of the venue beyond the scheduled time is prohibited；Extensions may be granted for special circumstances with the Library’s approval；If the Library has an urgent need to use the reserved venue space, it may notify the borrowing unit at least 7 days prior to the reserved date to cancel the use and coordinate to re‑schedule a later date and time；if postponement is not possible, the Library shall refund the venue space usage fee paid by the borrowing unit without interest，and the applicant may not seek any other compensation or reimbursements；The Library reserves the right for further review；Please call 06-2757575 Ext. #65793 for any queries。Guidelines：National Cheng Kung University Library Guidelines for the Management of Venue Space of the Library。Application System：University’s E‑campus Administrative Affair System。Relevant Information：National Cheng Kung University Library Rules for Reader Violations，Exhibition Schedule。 |
embedded |
2026-01-04 00:31:22 |
| 8474 |
https://www.lib.ncku.edu.tw/se... |
NCKU-National Cheng Kung University Library |
(國立成功大學圖書館的網頁內容)
Contact：Library Extension Services｜06-2757575 Ext. 65793 or 65790
Service Objects
Academic, artistic, and cultural exhibitions approved by the Library
Service Hours
During the Library’s opening hours
Application Process: Please go to the University's E‑campus Administrative Affair System to submit an application and email the activity plan to the Library; Applicants should complete the reservation registration two weeks to two months before the intended use; Student clubs of the University applying to use this venue should submit the approved activity consent form or activity plan from the Office of Student Affairs Office of the University, and the same applies to changes; Before applying, please check the exhibition/event calendar and call the Library to confirm the available time slots.
Fees: For use by on‑campus units or faculty/staff clubs, the principle is that no charge will be incurred; however, if fees are charged from participants or if there is external funding support, a venue usage fee should be paid; Student clubs of the University using the venue space should follow the relevant subsidy application procedures for venue usage fees outlined in the “National Cheng Kung University Directions for Subsidies for Funds for the Use of Assembly Venues by Student Self‑governing Organizations and Clubs of NCKU”; Charges are calculated in four‑hour units, for less than four hours will be charged for four hours; NCKU departments 500 NTD, Off‑campus units 1,000 NTD; For any unit hosting events that require library staff attendance and support, such as lectures, workshops, film screenings, post‑screening discussions, book launches, etc., during weekday evenings or on weekends, an additional fee of 1,000 NTD per session will be charged; The full usage fee should be paid in one lump sum at least seven days before the date of use, or it will be deemed as giving up the reservation made.
Note: 1. The use of this venue space shall be handled in accordance with the “National Cheng Kung University Library Guidelines for the Management of Venue Space of the Library”; 2. The unit borrowing the venue should designate one dedicated personnel on‑site to communicate with the Library staff and be present intermittently during the exhibition and event period for supervision and inspection; 3. Setting up the venue or posting promotional materials should be carried out after obtaining prior approval from the Library; 4. Violation of any of the following may result in the immediate termination by the Library of the current venue usage rights: (1) Drilling holes in the scenic walls or using a display method that damages the walls, carpets, or other surfaces; (2) Using the exhibition cabinets borrowed from the Library as stairs for construction or height measurement; 5. Personal belongings, equipment, and materials should be properly guarded by designated personnel; the Library bears no responsibility for any loss or damage; 6. After the exhibition concludes, the dedicated on‑site personnel is responsible for conducting an inventory and returning the venue and all equipment and materials used to the Library’s staff (or administrators); any dirt, garbage, waste, or items not belonging to the Library resulting from the venue’s use should be cleaned and removed on the same day, and the venue should be restored to its original condition; 7. Moving or installing various equipment and tools without prior permission from the Library is strictly prohibited; if improper use leads to damage or loss of facilities, it will be handled according to the “National Cheng Kung University Library Rules for Reader Violations”; (※ Do not move or plan to move fixed equipment such as sofas on the fourth floor. If any violation results in damage, it will be handled according to relevant procedures, and damaged equipment should be compensated at its value.) ; 8. During the exhibition construction period, please minimize noise and avoid disturbing other readers; if improvement is not observed after being reminded, the borrowing rights for that unit will be terminated after the conclusion of the exhibition; 9. For events such as opening ceremonies, interviews, speeches, etc., please notify the Library in advance to facilitate the preparation of microphone equipment and the creation of activity sound notice boards for other readers; if not notified in advance, the Library reserves the right to safeguard reader rights and decline the holding of an opening ceremony; 10. If the applying unit is unable to use the venue, it should apply to the Library for the cancellation or postponement at least seven days before the reserved date; applications not submitted within the deadline will not be accepted by the Library, except for cases where the inability to use the venue is due to natural disasters or force majeure; 11. In case of a violation of any circumstance outlined in Point 10 of the “National Cheng Kung University Library Guidelines for the Management of Venue Space of the Library”, the Library reserves the right to immediately terminate the applicant’s right to use the venue with no refund of fees; the applicant’s right to apply for borrowing the venue may be suspended for one year, and in severe cases, the matter may be reported to the University for further action or legal prosecution; 12. Adherence to the designated usage time is mandatory, and occupation of the venue beyond the scheduled time is prohibited; extensions may be granted for special circumstances with the Library’s approval; 13. If the Library has an urgent need to use the reserved venue space, it may notify the borrowing unit at least 7 days prior to the reserved date to cancel the use and coordinate to re‑schedule a later date and time; if postponement is not possible, the Library shall refund the venue space usage fee paid by the borrowing unit without interest, and the applicant may not seek any other compensation or reimbursements; 14. The Library reserves the right for further review. Please call 06-2757575 Ext. #65793 for any queries.
Guidelines: National Cheng Kung University Library Guidelines for the Management of Venue Space of the Library
Application System: University’s E‑campus Administrative Affair System
Relevant Information: National Cheng Kung University Library Rules for Reader Violations; Exhibition Schedule |
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NCKU-National Cheng Kung University Library |
(國立成功大學圖書館)
Contact: Library Extension Services 06-2757575 Ext. 65793 or 65790
Service Objects
Academic, artistic, and cultural exhibitions approved by the Library
Service Hours
During the Library’s opening hours
Application Process: Please go to the University’s E-campus Administrative Affair System to submit an application and email the activity plan to the Library. Applicants should complete the reservation registration two weeks to two months before the intended use; in case of scheduling conflicts with events held by the University or Library, the University or Library shall have priority. Student clubs of the University applying to use this venue should submit the approved activity consent form or activity plan from the Office of Student Affairs Office of the University, and the same applies to changes. Before applying, please check the exhibition/event calendar and call the Library to confirm the available time slots.
Fees: For use by on‑campus units or faculty/staff clubs, no charge will be incurred; however, if fees are charged from participants or if there is external funding support, a venue usage fee should be paid. Student clubs of the University using the venue space should follow the relevant subsidy application procedures for venue usage fees outlined in the National Cheng Kung University Directions for Subsidies for Funds for the Use of Assembly Venues by Student Self‑governing Organizations and Clubs of NCKU. Charges are calculated in four‑hour units; for less than four hours will be charged for four hours. NCKU departments 1,000 NTD; Off‑campus units 3,000 NTD. For any unit hosting events that require library staff attendance and support, such as lectures, workshops, film screenings, post‑screening discussions, book launches, etc., during weekday evenings or on weekends, an additional fee of 1,000 NTD per session will be charged. The full usage fee should be paid in one lump sum at least seven days before the date of use, or it will be deemed as giving up the reservation made.
Note: The use of this venue space shall be handled in accordance with the National Cheng Kung University Library Guidelines for the Management of Venue Space of the Library. The unit borrowing the venue should designate one dedicated personnel on‑site to communicate with the Library staff and be present intermittently during the exhibition and event period for supervision and inspection. Setting up the venue or posting promotional materials should be carried out after obtaining prior approval from the Library. Violation of any of the following may result in the immediate termination by the Library of the current venue usage rights: (1) the use of a destructive drilling method in venue setup that leads to damage to the Library’s original walls, floors, or other structures; (2) unauthorized expansion of the exhibition area during setup, affecting pathways and rights of other readers. Personal belongings, equipment, and materials should be properly guarded by designated personnel. The Library bears no responsibility for any loss or damage. After the exhibition concludes, the dedicated on‑site personnel is responsible for conducting an inventory and returning the venue and all equipment and materials used to the Library’s staff. Any dirt, garbage, waste, or items not belonging to the Library resulting from the venue’s use should be cleaned and removed on the same day, and the venue should be restored to its original condition. Moving or installing various equipment and tools without prior permission from the Library is strictly prohibited. If improper use leads to damage or loss of facilities, it will be handled according to the National Cheng Kung University Library Rules for Reader Violations. During the exhibition construction period, please minimize noise and avoid disturbing other readers; if improvement is not observed after being reminded, the borrowing rights for that unit will be terminated after the conclusion of the exhibition. For events such as opening ceremonies, interviews, speeches, etc., please notify the Library in advance to facilitate the preparation of microphone equipment and the creation of activity sound notice boards for other readers; if not notified in advance, the Library reserves the right to safeguard reader rights and decline the holding of an opening ceremony. Events involving food and beverages such as tea parties are not permitted in the lobby. If the applying unit is unable to use the venue, it should apply to the Library for the cancellation or postponement at least seven days before the reserved date. Applications not submitted within the deadline will not be accepted by the Library, except for cases where the inability to use the venue is due to natural disasters or force majeure. In case of a violation of any circumstance outlined in Point 10 of the National Cheng Kung University Library Guidelines for the Management of Venue Space of the Library, the Library reserves the right to immediately terminate the applicant’s right to use the venue with no refund of fees. The applicant’s right to apply for borrowing the venue may be suspended for one year, and in severe cases, the matter may be reported to the University for further action or legal prosecution. Adherence to the designated usage time is mandatory, and occupation of the venue beyond the scheduled time is prohibited; extensions may be granted for special circumstances with the Library’s approval. If the Library has an urgent need to use the reserved venue space, it may notify the borrowing unit at least 7 days prior to the reserved date to cancel the use and coordinate to re‑schedule a later date and time. If postponement is not possible, the Library shall refund the venue space usage fee paid by the borrowing unit without interest, and the applicant may not seek any other compensation or reimbursements. The Library reserves the right for further review. Please call 06-2757575 Ext. 65793 or email z10908064@ncku.edu.tw for any queries.
Guidelines: National Cheng Kung University Library Guidelines for the Management of Venue Space of the Library
Application System: University’s E-campus Administrative Affair System
Relevant Information: National Cheng Kung University Library Rules for Reader Violations; Exhibition Schedule |
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NCKU-National Cheng Kung University Library |
(以下為國立成功大學圖書館的網頁內容)，
Ruminating in the deep, as the sunlight slowly seeps. Lamps illuminate the dark, as the mind is calm not stark. Prayer and Meditation Space.
Origins：In response to the diverse cultural backgrounds and beliefs of our student body, NCKU Library has undertaken its first interfaith space renovation in over 20 years. The transformation involved repurposing the sofas on the northern side of the third floor, resulting in the creation of a dedicated Prayer and Meditation Space. This newly designed area not only exudes an aura of elegance and minimalism, fostering a serene and tranquil environment that offers respite from the pressures of daily life, but also serves as a sanctuary for interfaith prayer. We warmly invite you to explore and embrace this tranquil haven.
Service Recipients：Library visitors.
Opening Hours：NCKU Main Library Opening Hours.
Usage guidelines：This space provides individuals to carry out activities such as diverse belief prayers, meditation and stress relief. Please abide by the various usage rules and the following guidelines of the library, and kindly respect other user’s personal space. No reservation is required. For individual use only, groups of more than three are not allowed. Remove shoes upon entering and place them on the shoe rack. Please practice good personal hygiene habits and maintain cleanliness of the space. Please do not use the space if your body or personal belongings emit strong odors that may affect other users. Please refrain from lying down, sleeping and reading. Please engage in quiet conversations if necessary. Avoid making noise and loud sounds or use items that may do so, example: typing on laptop or others. If the space is unable to satisfy your needs or makes you feel uncomfortable, please readjust yourself (be considerate of others) or leave the space. Please take your personal belongings upon leaving and return the space’s equipment to its original state.
Related Links：NCKU Main Library commence trial use of its new “Prayer and Meditation Space”; Prayer and Meditation Space tour video. |
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NCKU-National Cheng Kung University Library |
(以下為國立成功大學圖書館的網頁內容)
**Quote**
Among these walls of bookshelves, lies books by giants themselves. Furniture of generations old, yet to someone they are gold. Rustic portraits on the wall, were there for you to recall. A century old of knowledge, anchored after a final voyage. ——Deutsche Bibliothek
**Origins**
Centuries of German classical knowledge rest within the grasp of your hand, a treasure trove of history and human wisdom. At NCKU Main Library's 'Deutsche Bibliothek' (German Bookroom), you can immerse yourself in rare European collections without needing to travel to Germany. Nestled on the 4th floor of NCKU Main Library, the Deutsche Bibliothek opened its doors on December 16, 2017, amassing a treasury of thousands of precious German books spanning four generations, from East to West Germany.This collection has woven a remarkable connection between Germany and Taiwan. Sabina Kowalewski, director of neonatology at the University of Bonn, cherished the hope that her books would continue to inspire and be read by countless individuals. Fulfilling Sabina's wish, her devoted apprentice, Dr. Jen-her Lu, has carried forward this legacy.The precious collection of books embarked on a journey across vast oceans, ultimately finding a home in Tainan.
Reflecting the Kowalewski family's passion for literature, reverence for wisdom, intergenerational affection, and the mentor-student bond, the Deutsche Bibliothek's collection remains a source of enrichment for readers. We cordially invite you to immerse yourself in the experience of the Deutsche Bibliothek.
**Service Recipients**
Library visitors
**Opening Hours**
NCKU Main Library Opening Hours
**Usage Guidelines**
No reservation is required, used by 2-3 person at a time; Please refrain from moving the furniture; Please place the book on a table after reading, do not put it back onto the bookshelf; Please take your personal belongings upon leaving; This space is designated for reading, please refrain from discussing and chatting.
**Related Links**
Intertwined by affection across four generations, the Deutsche Bibliothek has sailed the ocean and anchored in NCKU; Deutsche Bibliothek Introduction Video. |
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NCKU-National Cheng Kung University Library |
以下為國立成功大學圖書館的網頁內容
Contact：Library Extension Services｜(886)6-2757575 Ext. 65796、65790
Service for: All Patrons
Purposes: Applicants may apply to the Library to use the venue space for teaching, research, publication, promotion, or journalistic or other purposes; Applications with political, religious, or commercial agendas, and those in violation of good morals, affecting the reputation of the School, the image of the Library, or public safety will be rejected.
Application: Those who wish to use the space of the Library for photography or filming should fill out an application form and submit it with the planning materials and scripts to the Library for approval per the below regulations beforehand: Filming or photography with contents related to the National Cheng Kung University should be applied for approval at least 7 days ahead; Filming or photography with contents unrelated to NCKU and scripted filming sessions inside or outside NCKU should be applied for approval at least 20 days ahead; Special thanks to the NCKU Library should be made explicit upon publications or displaying of the images taken. Written agreements concerning rights & obligations can be made individually for special collaboration projects.
Time: The available time slots for filming or photography in the venue space are during the Library's opening hours from 9:00‑17:00, Monday through Friday. No access will be granted during special events and in the week prior to and during midterm and final exams.
Limitations: Filming and photography should not interfere with the normal operation of the Library and should strictly obey the provisions of the "NCKU Library Policy for Using Library", keeping the reading area quiet and not bringing food or drinks into the reading area; The use of props or equipment such as lights, tripods, rails, cantilevers, drapes, or the posting of posters or the erection of partitions shall be checked and approved by the relevant units of the Library beforehand; Applicants should comply with the Copyright Act, readers' right to privacy, and laws and regulations related to portrait rights. If the rights of readers or other third parties are involved, their prior consent should be obtained; The filmed images shall be used only for purposes stated for the filming, and the filming operation shall be consistent with the content stated in the application; Applicants are responsible for the safety of the personnel and maintaining the cleanness and integrity of the library's property. Applicants are fully liable to restoration or compensation for damage done to the building, facilities, or objects of the Library, or to third parties. Waste from photography or filming activities should be removed by the Applicant. If there is any abandoned property, the Library may dispose of it at the expense of the Applicant; Applicants are not allowed to assign or lend their filming permits to others. After permission is granted, please use valid personal identification card to exchange for film permits will be given to related personnel at the information desk at the day of filming or photography, and must be worn throughout the filming or photography process; The quiet reading area is excluded; In the event of a violation of the foregoing, the Library may immediately suspend the use of its premises by the Applicant, request the person to leave the premises, and demand compensation for damages. Such Applicants will be disqualified from filing applications for one year from the date of the violation; If the Library has an urgent need to use the venue space approved for photography or filming, it may notify the Applicant at least 3 days prior to the scheduled filming or photography date to cancel the use and coordinate to re‑schedule a later date and time. The Applicant may not seek any other compensation or reimbursements; Applicants may apply to the Library for a postponement 3 days prior to the scheduled filming or photography date. If the Applicant fails to apply for a postponement within the deadline, the Library may refuse the postponement request. However, the above shall not apply in the event of natural disasters or force majeure that prevents the Applicant's use of the venue space.
Guidelines: National Cheng Kung University Library Guidelines for the Management of Filming or Photography Applications in the Library
Application Form: NCKU Library Filming or Photography Application Form |
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NCKU-National Cheng Kung University Library |
(以下為國立成功大學圖書館的網頁內容)
Contact：Administration Division｜06-2757575 Ext. 65702｜cstsai@mail.ncku.edu.tw
Outdoor spaces of the main library
Corridor and outdoor square on the first floor；Outdoor grass square on the first floor；Outdoor square and gallery corridor on the first basement level
Target Users
The outdoor spaces are available for teaching, academic, artistic, literature and arts, and assembly related events, and they are available for borrowing by on‑campus units and clubs or by off‑campus units and organizations.
Service Hours
Semester：Monday~Friday 8:00~17:00，Saturday or Sunday 9:30~17:00，not available at night；Summer/Winter Break：Monday~Friday 9:00~17:00，Saturday 9:30~17:00，not available at night；The outdoor spaces are not available on library closed days.
Application
To apply for the use of the venue space, the borrowing unit should fill out a venue application form in the University’s e‑Administration system. Please read the rules and regulations of the venue in question and submit the event plan and other related documents to the Administration Division. If a student club of the University applies, it should submit a letter of approval from the Office of Student Affairs or an event plan, and the same applies to changes. Applicants who wish to borrow the venue space should submit their applications two weeks to two months before the scheduled borrowing date; however, for international conferences, seminars, performances or special needs, applications can be submitted six months in advance. Applicants who apply for the use of the venue space should pay the full usage fee at least seven days prior to the date of use, or they will be deemed to have given up the borrowing.
Rental Fee
There is no charge for the borrowing of the venue space by units, faculty, staff, or clubs of the University in principle. However, if a fee is charged to the participants or the borrowing unit receives external funding or subsidy, a usage fee for the venue space will be charged. Approval from the Office of Student Affairs shall be obtained if the student clubs of the University wish to use the venue space for an event. Applications for subsidies related to the use of venue space shall be handled in accordance with the National Cheng Kung University Student Autonomous Organizations and Student Clubs Fundings for Campus Venues Implementation Plan.
Venue：Corridor and outdoor square on the first floor – On‑campus unit 1,500 NT$ (tax included)，Off‑campus unit 3,000 NT$ (tax included).
Venue：Outdoor grass square on the first floor – On‑campus unit 2,000 NT$，Off‑campus unit 4,000 NT$.
Venue：Outdoor square and gallery corridor on the first basement level – On‑campus unit 1,500 NT$，Off‑campus unit 3,000 NT$.
Every 4 hours constitutes an interval; use hours less than one interval count as one interval. An additional fee of 10,000 NT$ is charged if the event renting a venue involves catering or snack vendors; catering must be approved by the on‑campus unit.
Note
If the Library has an urgent need to use the reserved venue space, it may notify the borrowing unit at least 7 days prior to the reserved date to cancel the use and coordinate a later date and time. The Library shall refund the venue space usage fee paid by the borrowing unit without interest, and the applicant may not seek any other compensation or reimbursements.
The borrowing units may apply to the Library for a postponement or a refund 7 days prior to the reserved date. If the borrowing unit fails to apply for a postponement or a refund within the deadline, the Library may refuse the request; however, the above shall not apply in the event of natural disasters or force majeure that prevents the borrowing unit’s use of the venue space.
The borrowing unit should designate a person on the site to liaise with the venue manager of the Library.
The borrowing unit shall be responsible for the safety of the event staff and the maintenance of the venue space in a clean and orderly manner to avoid disturbing others, and shall not ask the Library to perform any tasks unrelated to the use of the venue. After using the venue space, the borrowing unit should clean the environment and restore the venue to its original state. Please take care of the facilities and equipment of the venue. In the event of damage to equipment, building, or facilities, the borrowing unit shall be liable for damages.
Any equipment or services not provided by the Library shall be prepared by the borrowing unit with the consent of the Library; the borrowing unit shall be responsible for the custody of its own equipment or devices.
The borrowing units should pay attention to the safety of electricity use. If a large amount or special type of electricity is required, they should first contact the Library’s electrical and mechanical personnel for confirmation and should not connect the power without permission. Do not move or set up equipment and devices without permission. If the materials or facilities are damaged due to improper use, they shall be handled in accordance with the National Cheng Kung University Library Rules for Reader Violations.
Posters, marks, flags, banners posted or hung for the events must be approved by the Library in advance and should be removed immediately after the events; items not removed in time will be deemed as waste and the related processing cost will be borne by the borrowing unit.
Vehicles carrying equipment or items into the University or the Library before and after the event should be parked at the designated locations and driven away immediately after loading and unloading. Violators will be dealt with in accordance with the Regulations on the Control of Vehicles Driving on Campus at National Cheng Kung University.
The use of venue space by the borrowing units should not exceed the booked period. In case of special circumstances and with the consent of the Library, the usage time may be extended and fees will be charged in accordance with these guidelines.
Application Online
National Cheng Kung University e‑Administration system
Guideline
National Cheng Kung University Library Guidelines for the Management of Venue Space of the Library |
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NCKU-National Cheng Kung University Library |
(國立成功大學圖書館)
Contact：Knowledge Services Division｜(886)6-2757575 Ext. 65780｜em65780@email.ncku.edu.tw
Target Users
The service can be used only for educational training or promotion activities held by the NCKU library or activities approved by the NCKU library and the director and held either by the departments from NCKU or outside NCKU。
Application
Numbers of Users：15 to 60 people。To reserve the service, please fill out the Training Room Request Form in advance, and apply at the Reference Desk during the opening hours of the Library。Borrowers must apply no less than one week before the day of usage。The rental fee must be paid no later than 3 days before the reserved date, if necessary。
Notes
Users must inform librarians in advance if they need to install their own data or software on library computers and abide by relevant regulations and Copyright Laws。Users will be held legally responsible for violation of regulations and Copyright Law。Users cannot move or install any facilities or equipment in the Training Room。If the facilities or equipment are damaged due to improper use, the liability to pay compensation is required。If the user lends the room to others, use the room for other purposes other than those listed in the application form or violate government or school policies, the Library has the right to stop using the Training Room immediately and thereafter without protest。The user’s belongings, equipment and data are the user’s responsibility。The Library is not responsible for lost or damaged goods。It is prohibited to smoke and drink beverages in the Training Room。
Request Form
Training Room Request Form |
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NCKU-National Cheng Kung University Library |
(國立成功大學圖書館)
Contact：Library Extension Services｜(886)6-2757575 Ext. 65793 or 65790
Service for：All academic and artistic exhibitions organized by the Library；All academic and artistic exhibitions organized by NCKU staff, students, those invited by NCKU, or those from the non‑NCKU members, with an authorized approval by the director of the Library。
Application：Please fill out the request form online and have it approved by the library；The applicants should check out the Art Gallery Calendar for the use of the art gallery, and determine the exhibition with library staff before filing an official application。
Important Notes：Please abide by the schedule and relevant library regulations；Please maintain carefully the equipment and venue borrowed for the exhibition。
Charge：Charges are calculated in four‑hour units, for less than four hours will be charged for four hours；NCKU departments 1,000 NTD；Off‑campus units 2,000 NTD；Conference Center exhibition event 10,000 NTD；For any unit hosting events that require library staff attendance and support, such as lectures, workshops, film screenings, post‑screening discussions, book launches, etc., during weekday evenings or on weekends, an additional fee of 1,000 NTD per session will be charged。
Relevant Information：National Cheng Kung University Library Rules for Reader Violations；NCKU Art Gallery Calendar。 |
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NCKU-National Cheng Kung University Library |
(以下為國立成功大學圖書館的網頁內容)
Contact：Library Extension Services｜(886)6-2757575 Ext. 65796 or 65790｜pro@libmail.lib.ncku.edu.tw
Service for：Library Conference Center 可容納至多 170 人；使用時需至少 100 人；NCKU 各院系及校外單位可於 B1 樓保留圖書館會議中心作為學術會議、研討會、工作坊與校園活動之場地
Application：預約可於一週前進行，請填寫線上請款表或於工作時間內致電 65796 詢問時間以完成預約
Service Hours：學期：週一至週五 08:00‑17:00；週六或週日 09:30‑17:00，夜間不開放；暑假／寒假：週一至週五 09:00‑17:00；週六 09:30‑17:00，夜間不開放；圖書館關閉日會停止使用；查看時程表
Charge：收費按兩小時為單位，少於兩小時仍以兩小時計費。NCKU 各院系：週一至週五（辦公時間）NT$3,000；週六與週日 NT$6,000；加班 NT$8,000。校外單位：週一至週五 NT$6,000；週六與週日 NT$10,000；加班 NT$12,000。投影機租金 NT$500/2 小時，少於兩小時仍以兩小時計費。NCKU 各院系作為主辦單位且無參加者註冊費時，週一至週五原則免費，週六與週日 NT$6,000/2 小時；但若為共辦、收費或受校外補助者，週一至週五 NT$3,000/2 小時，週六與週日 NT$6,000/2 小時；少於 2 小時仍以 2 小時計費。加班使用須經圖書館批准。
Equipment：無線麥克風；網路節點及無線網路接取；投影機；投影幕；VIP 房
Note：會議中心禁止飲食；擁有會議或論文資源者，請提供兩份副本於圖書館以擴充館藏；未經批准不得張貼標誌、橫幅或傳單；花籃、垃圾或其他非圖書館之物品需自行清理；帶入自備視聽材料時須遵守著作權法；使用不當造成損害者須承擔賠償責任
Guidelines：待更新
Application Oline：請填寫線上請款表；設備申請
Online Tour：會議中心照片；會議中心與美術館地圖 |
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NCKU-National Cheng Kung University Library |
(以下為國立成功大學圖書館網頁內容)
Contact：Collection Management and Circulation Services Division｜(886)6-2757575 Ext. 65760 or 65763｜
Service for：For NCKU faculty, students and staff only. For using the Group Viewing Room, there should be at least 3-15 people.
Application：Users may reserve a room online or presenting an application at the Circulation Desk, Rooms can be reserved up to one week in advance, not allowed same user multiple rooms same time slot, The room reservations for the 7th day are available online from midnight every day, Booking must be made by a minimum of 3 eligible users, Users with reservations should collect the access key in person with their NCKU ID cards at the Library Circulation Desk on 1F, A user could only require one group viewing room one time for up to 4 hours, Unneeded reservation must be cancelled prior to the scheduled time via online booking system, Violation of this policy may result in suspension of library space booking privileges.
Equipment：3 rooms; each room can accommodate 10-15 people, 50 Plasma TV, Videocassette players(VHS), DVD/Blu-Ray Disc players, Tables, chairs, A digital whiteboard, A glass whiteboard, markers, a projector, A multifunctional lectern, A screen mirroring device, A Conference camera, Speakers and comfortable sofas.
Note：The group viewing room is for supporting NCKU curriculum, which requires viewing media materials (with public performance rights). Users should show up at the scheduled time and only will be 20 minutes of holding. For those who need to cancel the reservation should inform the Circulation Desk as soon as possible. For using the room it requires at least 3 users to show up at the scheduled time. Any damage is caused because of the improper use, the liability to pay compensation is required.
Request form：Auditorium/Group Viewing Room request form.
Photos： |
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NCKU-National Cheng Kung University Library |
(National Cheng Kung University Library)
Contact: Collection Management and Circulation Services Division｜(886)6-2757575 Ext. 65760 or 65763。
Service for: The Auditorium could hold up to 70 people。 For using the Auditorium, there should be at least 10 persons。
Open Hours: Regular Semester: 09:00 ~ 21:00 (Not available on library closed days)；Summer Break/Winter Break: 09:30 to 17:00 (Not available on library closed days)。
Application: The reservation is mandatory for using the Auditorium, reservation for up to 4 bookings can be made, when not reserved the Auditorium is available on a first‑come‑first‑served basis；To reserve the Auditorium, it is strongly suggested to check the bulletin online first and then download the request form or fill out the online request form for application；It is restricted to use the Auditorium for 4 hours at one time。
Equipment: A variety of equipment is available in the Auditorium to support use of collections：Overhead projector；Projection screen；Videocassette players (VHS)；DVD players；Microphones。
Note: The Auditorium is for supporting NCKU curriculum, which requires viewing media materials, it is not used for presentation or discussion sessions；Users should show up at the scheduled time and only will be 20 minutes of holding, for those who need to cancel the reservation should inform the Circulation Desk as soon as possible；If less than 10 persons show up for reserved viewing, they will be assigned to a group viewing room；The applicant unit is requested to provide its own laptop with an HDMI port；Any damage caused because of improper use, the liability to pay compensation is required。
Request form: Auditorium/Group Viewing Room request form |
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(以下為國立成功大學圖書館的網頁內容)
Contact: Collection Management and Circulation Services Division (886)6-2757575 Ext. 65752、65756; KnowLEDGE Learning Commons (886)6-2757575 Ext. 34906
Functions and purposes: The learning commons of the NCKU Library (named “KnowLEDGE”) is a “new place for learning”, located on the first and second floor of Dormitory No.3 of the University’s Ching‑Yeh Campus. As a campus hub for student‑centered learning activities, this venue is a shared or common space in which NCKU students, teachers and others can come together to interact and participate in various kinds of learning activities held there. The KnowLEDGE, as a new venue for knowledge construction, its space functions are: Service for NCKU faculty, students and staff to encourage them to engage in dialogue, discussion and creative learning; Service for campus activities approved by NCKU Library to build a cross‑over platform for interdisciplinary learning; Respond the students’ needs for self‑study by setting up a quiet reading room on the second floor.
Service for: The KnowLEDGE is open to NCKU faculty, students and staff only. It is not open to the public.
Open Hours: Open 24 hours (closure for cleaning, facility maintenance, national holiday or other factors will be announced in advance).
Interior space and equipment: Discussion and interaction area on the first floor: the area can hold up to 100 persons for individual or group study, discussion and campus activities approved by NCKU Library. A variety of spaces are provided in the Commons (Floor plan): Area A (Long tables area) equipped with 16 high chairs; Area B (Discussion area B) can hold up to 30 persons, equipped with combination tables, chairs and couch; wall cabinets have whiteboards; Area D (Discussion area D) can hold up to 20 persons, equipped with tables, benches and low stools; wall cabinets have whiteboards; Area E (Wooden stairs) allows sitting on the stairs and can be used together with Area D for activities; Area F (Wooden stages) equipped with 20 tables and seats. Projectors, wireless microphones and a 150‑inch projection screen (W305 cm × H334 cm) are available with reservation. The quiet reading room on the second floor is equipped with 80 seats for self‑study; users are asked to keep quiet. The rest area on the second floor is next to the quiet reading room and includes public facilities such as toilets and drinking fountains; round bar‑height tables, high chairs and colorful movable stools are provided for taking a break.
Access and activities application guide: Access to the KnowLEDGE Learning Commons is controlled by a door access system using ID card. NCKU faculty, students and staff must swipe their NCKU ID card when entering and leaving. In the discussion and interaction area on the first floor, NCKU faculty, students and staff are welcomed to take any seat for non‑activity use. For campus activities approved by NCKU Library, attendees must be limited to the reserved area; faculty, students and staff must swipe their ID card for entry, while guests must be accompanied by the activity applicants. If an activity has a reservation, it takes priority; the library prepares the reserved area one hour before the reservation and relocates other people accordingly. In the quiet reading room on the second floor, NCKU faculty, students and staff may take any seat on a first‑come, first‑served basis. Laptops or other noisy items are prohibited; those who fail to comply after persuasion will receive one violation point per the National Cheng Kung University Library Rules for Reader Violations and must leave immediately. For reserving and using activities, please fill out the online Venue Reservation Request Form for KnowLEDGE of NCKU Library. Requirements and rules for reservation are: each activity may involve 20 to 30 people; reservation time is from 1 hour after opening to 1 hour before closing (e.g., 10:00–22:00 during the semester); only one reservation is allowed for the same time period, and each reservation cannot exceed 4 hours; reservations may be made up to 6 months in advance, but the same applicant may make up to 6 reservations per year (January to December); reservations must be made at least 7 days prior; after approval, reservations are allocated by order of registration. Applicants or their authorized agents must borrow with their personal NCKU ID card within 20 minutes of the scheduled time at the KnowLEDGE service counter; failure to show up may result in cancellation. If an applicant cannot use the venue as scheduled, the reservation must be cancelled before the scheduled date; failure to cancel will incur one violation point per the library rules. Applications for merchandising or commercial activities are not approved. Applicants should contact the Collection Management Division (extension 65752 Miss Chen or 65756 Miss Lin) 2 working days (8:00–17:00, 12:00–13:00 lunch break) before the reserved date in person or by proxy to confirm venue use, and the applicant should assist staff with equipment setup and testing an hour before the event. Applicants should contact the library before posting activity posters at KnowLEDGE.
Important notice: Do not bring food, alcoholic drinks, prohibited items, or pets inside. While interactions and group discussions are encouraged, keep voices down. Respect other users’ rights and do not occupy seats; those who fail to improve after persuasion will receive one violation point per the library rules. Leaving a seat for more than 30 minutes is considered seat occupation and incurs one violation point; personal belongings left on an empty seat will be removed and collected at the service desk on the first floor by library staff or student assistants with no safekeeping responsibility. Secure your own personal items, belongings, books, and equipment; the venue bears no responsibility for loss and conducts daily clearing after closing. To maintain all users’ rights, the library checks NCKU ID cards at any time; users without an ID card, using another person’s ID card, forged ID card, or altered ID card must leave immediately upon discovery and will be penalized per the library rules. Do not park motor vehicles or bicycles at the Dormitory No. 3 parking lot on the Ching‑Yeh Campus.
Service Policy: National Cheng Kung University Library Rules for Use of Learning Commons.
Venue overview and related information: Location – 1st & 2nd Floor, Dormitory No. 3, Ching‑Yeh Campus. Floor plans – 1F and 2F. Brochure available. Photo descriptions – Gate; Discussion area B; Discussion area D/Wooden stairs; Long tables area; Wooden stages area; Wooden stairs area; The quiet reading room on the 2nd floor; The rest area on the 2nd floor. |
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(以下為國立成功大學圖書館單位的網頁內容)，Contact：Collection Management and Circulation Services Division｜(886)6-2757575 Ext. 65760 or 65763｜em65760@email.ncku.edu.tw；Service Targets: All NCKU students, faculty and staff members；Application: Users may reserve a room online or presenting an application at the Circulation Desk；Rooms can be reserved up to one week in advance and the same user cannot book multiple rooms in the same time slot；The room reservations for the 7th day are available online from midnight every day；Booking must be made by a minimum of 3 eligible users；Users with reservations should collect the access key in person with their NCKU ID cards at the Library Circulation Desk on 1F；A user could only require one group study room one time for up to 4 hours；Unneeded reservation must be cancelled prior to the scheduled time via online booking system，violation of this policy may result in suspension of library space booking privileges；Important Notes: Users should collect the access key within 20 minutes of the scheduled time with their NCKU ID cards at the Library Circulation Desk on 1F；Those who fail to show up on time may result in the cancellation of their booking；Failure to collect a key up to 3 times within a month will be subject to a month suspension of library space booking privileges；Smoking, eating, drinking, making excessive noise and other improper behaviors are strictly prohibited in the group study room；Any violators shall be deprived of the right to use a group study room immediately and be punished according to the National Cheng Kung University Library Rules for Reader Violations；Before leaving the room, users are required to return the room to its original setting and return the access key to the Circulation Desk；Users shall pay a processing fee of NT$ 100 every day for the unreturned key；Users who leave temporally should personally have their valuables safeguarded and the door locked and the key handed to the Circulation Desk；Users shall take responsibility for any damage to materials or facilities as a result of improper use；For any missing and damage of the key, users are responsible for all replacement cost of the key。 |
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NCKU-National Cheng Kung University Library |
(以下為國立成功大學圖書館內容)
NCKU‑National Cheng Kung University Library
聯絡: Collection Management and Circulation Services Division｜(886)6-2757575 Ext. 65760 or 65763
服務對象: NCKU faculty, graduate students, and undergraduate seniors enrolled in a thesis class, Experts or scholars invited by NCKU.
申請: 使用者可於線上或在借書台提出申請預約14個研究室，可提前一週預約；7日的研究室預約於每日午夜起線上開放；2個研究室不可線上預約，採先到先得，使用者於圖書館開館前於入口領號卡，每日只能領一次號卡；開館後，使用者於圖書館一樓借書台以NCKU身分證件領取存取鑰匙，學士班畢業生需提交論文班註冊文件；未按時到達或遺失號卡，預約可能取消；使用者每日只能使用一次研究室；不需要的預約必須於預定時間前取消，否則可能被停權。
重要注意事項: 使用者須於預定時間20分鐘內於圖書館一樓借書台以NCKU身分證件領取存取鑰匙，未按時到達可能取消預約；每月失竊鑰匙超3次將停權；禁止吸菸、吃喝、噪音或其他不當行為，違規即剝奪使用權並依「國立成功大學圖書館讀者違規處理辦法」處罰；離開前，使用者須將房間恢復原來狀態並將鑰匙歸還借書台，每日未歸還鑰匙須繳交NT$100處理費；臨時離開者應自行保管貴重物品並上鎖門，鑰匙交給借書台；使用者須對因不當使用造成的材料或設施損害負責；鑰匙遺失或損壞者，使用者須負擔所有更換費用。 |
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(國立成功大學圖書館)
Contact：Collection Management and Circulation Services Division｜(886)6-2757575 Ext. 65760 or 65763｜
Service for: The NCKU student associations or departments could borrow A/V materials from Circulation Desk for non-fee based and non-commercial purpose club activities；User guide: Applicant should fill out the request form and hand it to the Circulation Desk during the offices hours, 3 items could be borrowed up for 3-day loan, no renewal, An overdue fine of NT$30 per item per day will be charged for the late return, Please abide by the copyright regulations while using the materials. Unauthorized download, copy and any other matters involve violation of copyright regulations are “Forbidden”, Any damage is caused because of the improper use, the liability to pay compensation is required；Application Form: NCKU Library Media Materials Request Form for Club Activities, National Cheng Kung University Library Rules for Reader Violations。 |
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NCKU-National Cheng Kung University Library |
(以下為國立成功大學圖書館的網頁內容)
Contact: Collection Management and Circulation Services Division, (886)6-2757575 Ext. 65760 or 65763
Service for Patrons who wish to photograph the library materials for personal research or non-commercial purposes.
Location: Map Collections, B2F, NCKU Library.
Equipment: A self-service photography copy stand is available.
User guide: Please supply your own camera, Unauthorized download and copy are “Forbidden”, Any the damage is caused because of the improper use, the liability to pay compensation is required. |
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NCKU-National Cheng Kung University Library |
(國立成功大學圖書館)
Contact：Knowledge Services Division｜(886)6-2757575 Ext. 65780
Resources
The library provides Online English learning & testing database or systems through Internet. Please refer to “E-Resources Gateway” and click “Databases”.
Easy Test: Includes different courses (vocabularies, grammar, writing and oral courses) and practice tests of GEPT (elementary, intermediate high‑intermediate, and advanced level), TOEIC, TOEFL iBT, and IELTS；LiveABC Online Test Center: Includes practice tests of GEPT (elementary, intermediate high‑intermediate, and advanced level) and TOEIC；LiveABC English Learning Website: Offers different English learning courses, such as “English theater”, “office English” and “news English”；Each unit provides video clips with English and Chinese subtitles and interactive learning materials；CNN Interactive English: “CNN Interactive English” selects news articles from CNN programs to compile a variety of subjects, such as politics, economy, technology, entertainment, travel, and people；Every unit provides video clips with English and Chinese subtitles and interactive learning materials；(New)Live ABC/CNN learning website: A new platform from 2021；Studioclassroom WebEnglish: A platform includes the latest issue about Studioclassroom and Advanced, and it will be updated every month；VoiceTube: English videos include listening, oral practice, typing, and test；For example, TED Talks, TED Ed, BBC Learning English, CNN Student News, TOEIC (Level:Basic 250‑545; Intermediate 550‑780; Advanced 785‑990), TOEFL Test, Editor’s Choice, English Learning Tips, IMDb Top 250 Movies, Hot Movies, Movie Clips, Talk Show, Business, Kid, Music, Everyday English and so on；KONO Libraries: A lot of magazines about language learning。
How to use
The database can be accessed both the Online Search Area at the Library and through Internet on NCKU campus through Internet；Off‑campus access: NCKU faculty/staff/students can access the database through library RPA proxy server. For more information, please refer to “NCKU Library Off‑campus access”。 |
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NCKU-National Cheng Kung University Library |
(以下為國立成功大學圖書館網頁內容)
Contact: Knowledge Services Division｜(886)6-2757575 Ext. 65780｜
Resources: The NCKU Library provides Audio databases through Internet. Please refer to “E-Resources Gateway” and click “Databases”. The subscription of database could be different every year. We don’t subscribe any audio database in 2024, but some databases provide trial as below. Naxos Music Library: Trial deadline: ~2024/4/30; Naxos Music Library-Jazz: Trial deadline: ~2024/4/30; Naxos Music Library World: Trial deadline: ~2024/4/30; Naxos Spoken Word Library: Trial deadline: ~2024/4/30; Naxos Video Library: Trial deadline: ~2024/4/30; Medici.tv: Trial deadline: ~2024/5/31.
How to use: Online Audio Library could be accessed both in the NCKU Library electronic resources area and through the internet on NCKU campus; Off‑campus access: NCKU faculty/staff/students can access the database through library RPA proxy server. For more information, please refer to “NCKU Library Off‑campus access”. |
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(以下為國立成功大學圖書館的網頁內容)，
Contact: Collection Management and Circulation Services Division｜(886)6-2757575 Ext. 65760 or 65763
Service for: NCKU faculty/staff (part‑time faculty, exchange students included)/Retiree Library card holders/Faculty/Staff Family Dependant Library card holders/Alumnus Library card holders/Emeritus individuals or organizations/Library card holders/Volunteer Library card holders. For Part‑time students/extension courses students/One‑year library card members/other off‑campus members, the services are provided on a NT$50 fee‑based basis and the use duration is 4 hours for each person.
Hours: Retrieval of Multimedia Materials – Regular Semester 9:30~20:30 (12:00‑13:00 rest), Summer/Winter Breaks 10:00~17:00. Multimedia Viewing Carrels – Regular Semester 9:30~21:00 (12:00‑13:00 rest), Summer/Winter Breaks 10:00~17:30.
User guide: Materials of the Media Center collection may be used on‑site in the Center only. Unauthorized download and copy are “Forbidden”. If you wish to photocopy the Media Center paper collection, please register at the information desk for borrowing materials and return them within 30 minutes. Borrowing and Returning – The materials could be checked out for teaching purpose. Each faculty could borrow up to 3 items for 7 days. An overdue fine of NT$30 per item per day will be charged for the late return. Course Reserve materials – The Course Reserved materials are shelved in designated location. All the reserved items are for the in‑house use only, but could be checked out for a one‑day class use. Exhibit materials – Exhibit materials are shelved in designated location during the exhibition period and are for in‑house use only.
Note: It is prohibited to use Media Center’s equipment for non‑Media Center items. It is prohibited to use Media Center equipment to download or copy items. NCKU faculties, students and staff could reserve a viewing booth and materials within 7 days. The booking must be made one day ahead the using date. The NCKU student associations could borrow materials from Media Center for non‑fee based and non‑commercial purpose club activities. Any damage caused because of improper use requires liability to pay compensation.
Related rules: National Cheng Kung University Library Rules for Loan Services of Books and Materials; National Cheng Kung University Library Rules for Reader Violations; National Cheng Kung University Library Rules for Use of Facilities. |
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NCKU-National Cheng Kung University Library |
(以下為國立成功大學圖書館 Periodicals Division的網頁內容)
Contact：Periodicals Division｜(886)6-2757575 Ext. 65732 (Chinese), 65731 (English)｜
Service Targets：NCKU faculty, staff, and students.
Regulations for Recommendation：Recommended Contents：Chinese and foreign-language periodicals, Technical reports, Newspapers. Principles for Recommendation：One patron can recommend only two Chinese periodicals and one general foreign-language periodical at most during a semester, Academic periodicals can only be recommended by respective departments, Technical reports can only be recommended by respective departments, The recommendation of newspapers should be assessed prior to subscription, Recommended materials will be assessed by the Periodical Section before subscription, All recommended periodicals should correspond to the collection policies of the Library. Methods for Recommendation：Academic periodicals and technical reports should be recommended by respective departments, To maintain the practicability of current periodicals, the renewals should be reviewed every year, Deletions or additions to current periodicals should be discussed and passed by respective departments, The purchase of back-issue periodicals will be based on the department’s recommendations and budget, Please use the “Suggest a Purchase of Library Materials” for recommendation of general Chinese and foreign-language periodicals as well as newspapers, The Library will forward the recommendations to related units.
Service Policy：National Cheng Kung University Operational Directions for Collecting Library Journals. |
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(以下為國立成功大學圖書館網頁內容)
Contact：Acquisitions & Cataloging Division｜(886)6-2757575 Ext. 65726
Required materials & documents：All acquired books and multimedia materials, Purchase permits (including invoice and list), Property cards (in triplicate)
The books/materials (both acquisitions and donations) should be applicable to “The collection development policy of National Cheng Kung University Library” and adhere to the copyright laws. The Library does not accept the books with notes, corrections, underlines, breakages, missing pages or water-damaged and insect-damaged.
Multimedia materials (both acquisitions and donations) shall be proper edition for public use and have been granted with public performance license. Only that of professor’s personal project is excluded.
The following information are required to mark at the rear page of printed materials：Department: name of department; Source: name of supplier; Price: selling price in NT$.
For an urgent need, please fill out the Application Form for Rush Cataloging while asking for library receipt procedure. The items generally can be checked out in 3 to 5 working days at the circulation desk, but it may take longer if more items are required.
Service Policy：National Cheng Kung University Library Operation Regulations for Acquiring Books and Other Materials; National Cheng Kung University Guidelines for Collecting Multimedia Audio‑visual Materials. |
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(以下為國立成功大學圖書館的網頁內容)，
Book donations will be temporarily suspended from April 1, 2025。
Donors：Both individuals and groups are welcome。
Policy：According to National Cheng Kung University Library Operation Regulations for Acquiring Books and Other Materials。
Acceptance Guidelines：All gifts to the Library should fall within the scope of the Library’s collection development policy and the acceptance criteria；gifts must adhere to copyright law；audio‑visual materials should be standard edition for public use or have been granted with public performance license；unqualified materials include titles the Library already owns, not NCKU PhD and Masters theses, institution introductions / study guidelines / test prep books / address books / incomplete law, standard or regulation materials / conference papers only with agenda or summary / religious pamphlet / numerology information / books of improper social manners & etiquette / absurdity books fall outside of library collecting policy；the physical condition of the materials with notes, corrections, underlines / defaced / single part of a set；outdated scientific books (acceptable science and technology books should be published in the last 5 years, computer books in the last 2 years) / similar titles the library already held (unless an otherwise special edition)。
Conditions, Use, Acknowledgement：Donor’s name will be placed on the book’s last page of the gifts accepted；the Library makes written acknowledgement of all gifts；for materials deemed “expensive, valuable and rare”, the Library Affairs Meeting will arrange rewards to appreciate in return；the Library will get the donors’ approval in advance and honor their names on the Library’s website, and make an application for the University’s official acknowledgement of gifts；donors cannot designate how they would like their gifts to be used or located；materials not added to the collections may be offered to another library or disposed of through other means。
Contacting the Library：Persons considering a gift of books to the Library should mail to Acquisitions and Cataloging Division of National Cheng Kung University Library (Please indicate “Gifts” on the front cover of the package)；gifts are received by personnel at the Circulation Desk on the 1st floor of the Library；upon receipt of your donation, you will be asked to complete a Library Gift Form；for large donations, the Library encourages donors to provide a list of materials including the title or description of the items, dates, and general condition of the material；the Library will review the list and contact the donor to discuss whether or not the gift would be of value to the Library and delivery details；for general questions regarding gifts, you may also contact (886) 6-2757575 Ext.65726 for books or Ext.65732 for periodicals。
Contact：Acquisitions & Cataloging Division｜(886)6-2757575 Ext. 65726 (Books), 65732 (Periodicals). |
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NCKU-National Cheng Kung University Library |
（以下為國立成功大學圖書館的網頁內容）Temporary Suspension of Book Donation Service：日期 2025-04-01。附加檔案：Announcement of Temporary Suspension of Book Donation Service。聯絡人：Acquisition and Cataloging Division，電話 Ext. 65726，電子郵件 em65710@email.ncku.edu.tw。 |
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(以下為國立成功大學圖書館的網頁內容)，Contact：Acquisitions & Cataloging Division｜(886)6-2757575 Ext. 65714、65721。Book Web Portals: Western Books: Amazon、BookFinder、AbeBooks、Barnes & Noble、Select Books Online (Singapore)。Japanese Books: Kinokuniya。Simplified Chinese Books: Lai’s Book、abooks.com.tw、Joint Publishing、Wanjuan。 |
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(National Cheng Kung University Library)
Contact：Acquisitions & Cataloging Division（886）6-2757575 Ext. 65727（Chinese、Japanese），65723、65714（Foreign），em65710@email.ncku.edu.tw。
Eligible User：All NCKU faculty, staff and students。
Service description：
1. Funds authorized by NCKU academic departments
• User：NCKU academic departments。
• Policy：Standard Service：10% of the departmental allocations or the balance after that expending on journal subscriptions and databases will be allocated as book budget of the current fiscal year。 Departments should use the form “Book Recommendation List” for requests and both send the Excel file and print‑out list with department head’s signature to the Acquisition & Cataloging Division（Medical College please send to Kun‑Yen Medical Library）。 All requests will be collected by the end of September，and after the deadline the library reserves the right to decide what to purchase from the leftover funds。
• Rush Service：Urgent items for teaching and research are available with a rush service. This service is applied on its departmental allocations。 The faculty member should fill out the form “Application Form for Rush Purchase”，get approval of the department head and then forward to the Acquisitions & Cataloging Division。 The library will fulfill the order for rush service by Air Mail。
• Recommenders who are eligible for priority borrowing will be notified by e‑mail when the items are ready for use。
• For new books information please refer to “Selected New Book Information for Recommendation”。
2. Recommendation by readers
• User：All NCKU faculty, staff and students。
• Policy：
1. Use “Suggest a Purchase of Library Materials” for online recommendation。
2. All acquisitions shall be appropriate to the fulfillment of our collection development policy and be considered within the constraints of our budget。
3. The Library purchases comprehensive and general books/materials in principle. Demand for scholarly ones is subjected to be recommended by academic department with financial support。
4. The Library conducts purchase activities based on Government Procurement Law, therefore the library purchases and receipt procedure should be made in bulk. Recommenders who are eligible for priority borrowing will be notified by e‑mail when the items are ready for use。
5. Five is the maximum number of purchase quantity limit for Chinese books, three for foreign books, and a maximum amount of NT$3,000 for multimedia materials for one person in one semester。
6. As to the materials beyond the limit of quantity and budget, we may keep them on the waiting list and do as many appropriate purchases as possible. But the recommenders are not given priority borrowing privileges on these items。
3. Purchasing and cataloging procedure
• The practice of library purchase activities bases on Government Procurement Law, therefore ordering and receiving should be performed in batch processing. We cannot always make the delivery meet our reader’s expectations, but we try hard to improve the internal workflow and make newly acquired items available as soon as possible。
• For overseas acquisitions, the average turnaround time from order placement to ready for use ranges from 3 to 4 months（regular time period）：
- Preparing book lists 0.5 month。
- Ordering process 2 months。
- New arrivals in process 1–2 months。
- Estimated delivery time 3–4 months。
• For domestic acquisitions, the average turnaround time from order placement to ready for use ranges from 2 to 2.5 months（regular time period）：
- Preparing book lists 0.5 month。
- Ordering process 0.5–1 month。
- New arrivals in process 1 month。
- Estimated delivery time 2–2.5 months。
• The average turnaround time of a rush order is about 1–2 months for overseas acquisitions and 1–2 weeks for domestic acquisitions。
• Rush cataloging request：Complete “Application Form for Rush Cataloging” to request rush cataloging and processing of a title(s) that is shown in the Library Catalog as “In Process”。 This request is only available for NCKU faculty who recommend the purchase。
• Preview service for in-process item：If you need an in-process item (the book is in the library but cataloging has not been completed), bring your library/university card to the circulation counter (1F)。 This service can be used by NCKU students, staff and faculty during office hours。
Download the forms：
• Book Recommendation List
• Application Form for Rush Cataloging
• Application Form for Rush Purchase
• Application Form for Departments/Faculty Members Purchasing Academic Materials Abroad
Service Policy：
• National Cheng Kung University Library Operation Regulations for Acquiring Books and Other Materials
• National Cheng Kung University Guidelines for Collecting Multimedia Audio‑visual Materials
• National Cheng Kung University Library – The Essentials of Electronic Database Collecting |
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NCKU-National Cheng Kung University Library |
(以下為國立成功大學圖書館)
Contact：Customer Service 02-22999889 ext. 8577 LINE ID @323tdgdv Knowledge Services Division (886)6-2757575 Ext. 65780 Administration Division (886)6-2757575 Ext. 65700
Photocopy Service
Photocopying, printing, and cloud printing services are available in the Main Library and the Kun-Yen Medical Library.
Payment Methods
Electronic Stored Value Cards: Easy Card / iPass, Mobile Payment: Apple Pay / Samsung Pay / Google Pay / 台灣Pay / Line Pay, Credit Card: Visa / Master / JCB card, Pay by cash: If you want to pay by cash, please contact the staff at the Reference Desk on the first floor of the Main Library or the Circulation Desk on the first floor of the Kun Yen Medical Library.
Photocopying and Printing Prices
A4 per page: Black and white: NT$1, Colour: NT$5; A3 per page: Black and white: NT$2, Colour: NT$10; Double-sided counts as two pages; It will be unavailable to print or copy if the Easy Card or iPass balance is not enough to pay the photocopying or printing fees.
Printer Locations
Main Library 1F photocopy room: Color copier Y, Printing Y, Photocopying Y, Scanning Y; Main Library 3F photocopy room: Color copier Y, Printing Y, Photocopying Y, Scanning Y; Kun-Yen Medical Library 1F Information Search Area: Color copier Y, Printing Y, Photocopying Y, Scanning Y.
User guide
User guide
Copyright
Please note that all copying and printing is subject to Copyright. It is your responsibility to ensure that your copying is legal. (Please refer to the page of Propagation of Intellectual Property Rights Compliance.) |
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NCKU-National Cheng Kung University Library |
(國立成功大學圖書館)
Contact：Collection Management and Circulation Services Division (886)6‑2757575 Ext. 65756，1F Circulation Desk (886)6‑2757575 Ext. 65760 or 65763。
Service Goals：提供使用者借閱位於本館 B2 特別裝訂材料區（Closed Stacks）的館藏。
Service Recipients：所有使用者。
Material Scope：中文硬皮書（線編），具有特別裝訂格式的書籍。
Service Description：書籍存於 B2 特別裝訂材料區為 Closed Stacks 管理，但可借閱，館藏位置顯示為「Main Library B2 Special Binding Materials Area (Closed Stacks) (Collection Request)」於 Discovery System；需要存取 B2 特別裝訂材料區之讀者，可於本館各樓層服務櫃填寫館藏申請表或於 Discovery System 申請（校內讀者可登入預約，校外讀者須填寫校外讀者館藏申請表）；收到館藏申請表後，館員於營業日每日取回館藏，並於取回後之一個營業日內以電子郵件或電話通知申請人；申請人收到電子郵件通知後，請於規定時間內於本館 1F 借閱櫃領取物品，否則該物品將重新上架；讀者借閱 B2 特別裝訂材料區（Closed Stacks）之館藏，須遵守《國立成功大學圖書館書籍及材料貸閱服務規則》之相關規定。 |
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